Synthesis of Hollow-Structured Nano- and Microspheres from Pectin in a Nanodroplet Emulsion

dc.creatorReis, AV
dc.creatorGuilherme, MR
dc.creatorPaulino, AT
dc.creatorMuniz, EC
dc.creatorMattoso, LHC
dc.creatorTarnbourgi, EB
dc.date2009
dc.dateFEB 17
dc.date2014-11-15T16:32:38Z
dc.date2015-11-26T16:12:22Z
dc.date2014-11-15T16:32:38Z
dc.date2015-11-26T16:12:22Z
dc.date.accessioned2018-03-28T23:00:38Z
dc.date.available2018-03-28T23:00:38Z
dc.identifierLangmuir. Amer Chemical Soc, v. 25, n. 4, n. 2473, n. 2478, 2009.
dc.identifier0743-7463
dc.identifierWOS:000263373600084
dc.identifier10.1021/la803313j
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79240
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/79240
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79240
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267256
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionHollow-structured nano- and microspheres with diameters ranging from 24 mu m to 160 nm were successfully produced from chemically modified pectin (Ma-Pec) through a two-step synthesis. In a first step, the Pec was modified with glycidyl methacrylate (GMA) in a heterogeneous phase system, indeed consisting of water-soluble Pec and water-insoluble GMA, via an interfacial reaction at the interface of the GMA-water phase system after 12 h under continuous stirring of 1000 rpm at 60 degrees C. In a second step, the spheres were prepared in a water-in-benzyl alcohol nanodroplet emulsion at 12000 rpm under a bubbling stream of nitrogen in the presence of sodium persulfate, as initiator, and TEMED, as catalytic agent. FT-IR spectra revealed that the vinyl groups (C=C) coming from the GMA were attached onto backbone of the polysaccharide. (13)C-CP/MAS NMR spectra demonstrated that the spheres were formed via carbon-carbon pi-bonds on Ma-Pec in the water phase, for the duration of the dispersion stage. The dark center (an empty core) and edge of the hollow spheres could be easily identified by SEM micrographs. This type of polymer structure represents a class of unique material with particular importance in terms of state-of the-art applications in both nano- and microencapsulation of drugs, for example, protection shields of biologically active agents.
dc.description25
dc.description4
dc.description2473
dc.description2478
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundagdo de Amparo a Pesquisa do Estado de Sao Paulo [06/50952-4]
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundagdo de Amparo a Pesquisa do Estado de Sao Paulo [06/50952-4]
dc.languageen
dc.publisherAmer Chemical Soc
dc.publisherWashington
dc.publisherEUA
dc.relationLangmuir
dc.relationLangmuir
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectColonic Drug-delivery
dc.subjectGlycidyl Methacrylate
dc.subjectRelease
dc.subjectFabrication
dc.subjectHydrogels
dc.subjectDextran
dc.subjectSpheres
dc.subjectTransesterification
dc.subjectPolysaccharide
dc.subjectPolymerization
dc.titleSynthesis of Hollow-Structured Nano- and Microspheres from Pectin in a Nanodroplet Emulsion
dc.typeArtículos de revistas


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