Homogenous demineralized dentin matrix for application in cranioplasty of rabbits with alloxan-induced diabetes: Histomorphometric analysis

dc.creatorGomes, MF
dc.creatorde Freitas Banzi, EC
dc.creatorde Souza Setubal Destro, MF
dc.creatorLavinicki, V
dc.creatorVilela Goulart, MG
dc.date2007
dc.dateNOV-DEC
dc.date2014-11-15T15:18:44Z
dc.date2015-11-26T16:11:49Z
dc.date2014-11-15T15:18:44Z
dc.date2015-11-26T16:11:49Z
dc.date.accessioned2018-03-28T23:00:19Z
dc.date.available2018-03-28T23:00:19Z
dc.identifierInternational Journal Of Oral & Maxillofacial Implants. Quintessence Publishing Co Inc, v. 22, n. 6, n. 939, n. 947, 2007.
dc.identifier0882-2786
dc.identifierWOS:000251775800009
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69622
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69622
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69622
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267180
dc.descriptionPurpose: The aim of this work was to evaluate the bone-repair process after implantation of homogenous demineralized dentin matrix (HDDM) slices in surgical defects created in the parietal bones of rabbits with alloxan-induced diabetes. Materials and Methods: Forty-eight rabbits were selected and divided into 4 groups of 12 rabbits: the control group, diabetic rabbits (D), diabetic rabbits with a PTFE barrier (D-PTFE), and diabetic rabbits with a PTFE barrier and with slices of homogenous demineralized dentin matrix (D-PTFE+HDDM). The diabetic animals received a single dose of alloxan monohydrate (90 mg/kg) intravenously on the marginal ear vein, and their blood glucose was verified daily. The rabbits were sacrificed after 15, 30, 60, and 90 days. The histologic findings show both better bone structure and significantly greater bone density, as determined by histomorphometric analysis, for the D-PTFE + HDDM group than for the other 3 groups (P <.01). It was also observed that the mean bone density increased gradually from 15 to 90 days (except in the D-PTFE group). Conclusion: It was concluded that the HDDM was biocompatible with the bone repair of diabetic rabbits and that HDDM slices stimulated bone tissue formation. Facilitation of bone repair with HDDM could be useful in diabetic patients.
dc.description22
dc.description6
dc.description939
dc.description947
dc.languageen
dc.publisherQuintessence Publishing Co Inc
dc.publisherHanover Park
dc.publisherEUA
dc.relationInternational Journal Of Oral & Maxillofacial Implants
dc.relationInt. J. Oral Maxillofac. Implants
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectbone repair
dc.subjectdiabetes mellitus
dc.subjecthomogenous demineralized dentin matrix
dc.subjectmonohydrated alloxan
dc.subjectTissue Engineering Applications
dc.subjectBone
dc.subjectDifferentiation
dc.subjectInduction
dc.subjectDefects
dc.subjectDogs
dc.titleHomogenous demineralized dentin matrix for application in cranioplasty of rabbits with alloxan-induced diabetes: Histomorphometric analysis
dc.typeArtículos de revistas


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