Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp

dc.creatorBrito, AS
dc.creatorArimateia, DS
dc.creatorSouza, LR
dc.creatorLima, MA
dc.creatorSantos, VO
dc.creatorMedeiros, VP
dc.creatorFerreira, PA
dc.creatorSilva, RA
dc.creatorFerreira, CV
dc.creatorJusto, GZ
dc.creatorLeite, EL
dc.creatorAndrade, GPV
dc.creatorOliveira, FW
dc.creatorNader, HB
dc.creatorChavante, SF
dc.date2008
dc.date37196
dc.date2014-11-15T14:54:13Z
dc.date2015-11-26T16:11:45Z
dc.date2014-11-15T14:54:13Z
dc.date2015-11-26T16:11:45Z
dc.date.accessioned2018-03-28T23:00:15Z
dc.date.available2018-03-28T23:00:15Z
dc.identifierBioorganic & Medicinal Chemistry. Pergamon-elsevier Science Ltd, v. 16, n. 21, n. 9588, n. 9595, 2008.
dc.identifier0968-0896
dc.identifierWOS:000260134400020
dc.identifier10.1016/j.bmc.2008.09.020
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77806
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77806
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77806
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267165
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug. (C) 2008 Elsevier Ltd. All rights reserved.
dc.description16
dc.description21
dc.description9588
dc.description9595
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationBioorganic & Medicinal Chemistry
dc.relationBioorg. Med. Chem.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectGlycosaminoglycans
dc.subjectCrustacean heparin-like compound
dc.subjectAnti-inflammatory activity
dc.subjectHeparin
dc.subjectAnticoagulant activity
dc.subjectInvertebrate
dc.subjectHemorrhagic activity
dc.subjectLitopenaeus vannamei
dc.subjectMatrix metalloproteinases
dc.subjectEscherichia-coli K5
dc.subjectTransmigration In-vitro
dc.subjectP-selectin
dc.subjectAnomalocardia-brasiliana
dc.subjectMatrix Metalloproteinases
dc.subjectCapsular Polysaccharide
dc.subjectAntithrombotic Agent
dc.subjectAcute-inflammation
dc.subjectEndothelial-cells
dc.subjectSulfate
dc.titleAnti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución