dc.creator | Brito, AS | |
dc.creator | Arimateia, DS | |
dc.creator | Souza, LR | |
dc.creator | Lima, MA | |
dc.creator | Santos, VO | |
dc.creator | Medeiros, VP | |
dc.creator | Ferreira, PA | |
dc.creator | Silva, RA | |
dc.creator | Ferreira, CV | |
dc.creator | Justo, GZ | |
dc.creator | Leite, EL | |
dc.creator | Andrade, GPV | |
dc.creator | Oliveira, FW | |
dc.creator | Nader, HB | |
dc.creator | Chavante, SF | |
dc.date | 2008 | |
dc.date | 37196 | |
dc.date | 2014-11-15T14:54:13Z | |
dc.date | 2015-11-26T16:11:45Z | |
dc.date | 2014-11-15T14:54:13Z | |
dc.date | 2015-11-26T16:11:45Z | |
dc.date.accessioned | 2018-03-28T23:00:15Z | |
dc.date.available | 2018-03-28T23:00:15Z | |
dc.identifier | Bioorganic & Medicinal Chemistry. Pergamon-elsevier Science Ltd, v. 16, n. 21, n. 9588, n. 9595, 2008. | |
dc.identifier | 0968-0896 | |
dc.identifier | WOS:000260134400020 | |
dc.identifier | 10.1016/j.bmc.2008.09.020 | |
dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77806 | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/77806 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/77806 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1267165 | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description | The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug. (C) 2008 Elsevier Ltd. All rights reserved. | |
dc.description | 16 | |
dc.description | 21 | |
dc.description | 9588 | |
dc.description | 9595 | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.language | en | |
dc.publisher | Pergamon-elsevier Science Ltd | |
dc.publisher | Oxford | |
dc.publisher | Inglaterra | |
dc.relation | Bioorganic & Medicinal Chemistry | |
dc.relation | Bioorg. Med. Chem. | |
dc.rights | fechado | |
dc.rights | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dc.source | Web of Science | |
dc.subject | Glycosaminoglycans | |
dc.subject | Crustacean heparin-like compound | |
dc.subject | Anti-inflammatory activity | |
dc.subject | Heparin | |
dc.subject | Anticoagulant activity | |
dc.subject | Invertebrate | |
dc.subject | Hemorrhagic activity | |
dc.subject | Litopenaeus vannamei | |
dc.subject | Matrix metalloproteinases | |
dc.subject | Escherichia-coli K5 | |
dc.subject | Transmigration In-vitro | |
dc.subject | P-selectin | |
dc.subject | Anomalocardia-brasiliana | |
dc.subject | Matrix Metalloproteinases | |
dc.subject | Capsular Polysaccharide | |
dc.subject | Antithrombotic Agent | |
dc.subject | Acute-inflammation | |
dc.subject | Endothelial-cells | |
dc.subject | Sulfate | |
dc.title | Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp | |
dc.type | Artículos de revistas | |