dc.creatorBalthazar, MLF
dc.creatorYasuda, CL
dc.creatorPereira, FR
dc.creatorPedro, T
dc.creatorDamasceno, BP
dc.creatorCendes, F
dc.date2009
dc.dateAPR
dc.date2014-11-15T13:14:31Z
dc.date2015-11-26T16:11:19Z
dc.date2014-11-15T13:14:31Z
dc.date2015-11-26T16:11:19Z
dc.date.accessioned2018-03-28T22:59:49Z
dc.date.available2018-03-28T22:59:49Z
dc.identifierEuropean Journal Of Neurology. Wiley-blackwell Publishing, Inc, v. 16, n. 4, n. 468, n. 474, 2009.
dc.identifier1351-5101
dc.identifierWOS:000264372900017
dc.identifier10.1111/j.1468-1331.2008.02408.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61758
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61758
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61758
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267059
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionGrey matter (GM) atrophy has been demonstrated in amnestic mild cognitive impairment (aMCI) and mild Alzheimer's disease (AD), but the role of white matter (WM) atrophy has not been well characterized. Despite these findings, the validity of aMCI concept as prodromal AD has been questioned. We performed brain MRI with voxel-based morphometry analysis in 48 subjects, aiming to evaluate the patterns of GM and WM atrophy amongst mild AD, aMCI and age-matched normal controls. Amnestic mild cognitive impairment GM atrophy was similarly distributed but less intense than that of mild AD group, mainly in thalami and parahippocampal gyri. There were no difference between aMCI and controls concerning WM atrophy. In the mild AD group, we found WM atrophy in periventricular areas, corpus callosum and WM adjacent to associative cortices. We demonstrated that aMCI might be considered a valid concept to detect very early AD pathology, since we found a close proximity in the pattern of atrophy. Also, we showed the involvement of WM in mild AD, but not in aMCI, suggesting a combination of Wallerian degeneration and microvascular ischaemic disease as a plausible additional pathological mechanism for the discrimination between MCI and AD.
dc.description16
dc.description4
dc.description468
dc.description474
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherWiley-blackwell Publishing, Inc
dc.publisherMalden
dc.publisherEUA
dc.relationEuropean Journal Of Neurology
dc.relationEur. J. Neurol.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectAlzheimer's disease
dc.subjectamnestic mild cognitive impairment
dc.subjectvoxel-based morphometry
dc.subjectwhite matter
dc.subjectVoxel-based Morphometry
dc.subjectIn-vivo
dc.subjectCorpus-callosum
dc.subjectTemporal-lobe
dc.subjectDementia
dc.subjectDamage
dc.subjectAd
dc.subjectProgression
dc.subjectDepression
dc.subjectReduction
dc.titleDifferences in grey and white matter atrophy in amnestic mild cognitive impairment and mild Alzheimer's disease
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución