Regulation of insulin-stimulated tyrosine phosphorylation of Shc and Shc/Grb2 association in liver, muscle, and adipose tissue of epinephrine- and streptozotocin-treated rats

dc.creatorPaez-Espinosa, V
dc.creatorRocha, EM
dc.creatorVelloso, LA
dc.creatorSaad, MJA
dc.date2001
dc.dateAPR
dc.date2014-11-15T12:39:28Z
dc.date2015-11-26T16:11:14Z
dc.date2014-11-15T12:39:28Z
dc.date2015-11-26T16:11:14Z
dc.date.accessioned2018-03-28T22:59:43Z
dc.date.available2018-03-28T22:59:43Z
dc.identifierEndocrine. Humana Press Inc, v. 14, n. 3, n. 295, n. 302, 2001.
dc.identifier0969-711X
dc.identifierWOS:000169301400003
dc.identifier10.1385/ENDO:14:3:295
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80058
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/80058
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80058
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267038
dc.descriptionShc protein phosphorylation has been extensively characterized as the initial step that activates a complex mitogenic pathway through its association with Grh2. In the present study, we investigated the adrenergic control of insulin-induced She phosphorylation and Shc-Grb2 association, and the modulating effect of streptozotocin-induced diabetes mellitus on She phosphorylation and Shc/Grb2 association. Acute treatment with epinephrine, which leads to a normoglycemic insulin-resistant state, does not affect insulin-induced She tyrosine phosphorylation or Shc-Grb2 association in liver, muscle, or fat. By contrast, a significant increase in insulin-induced She phosphorylation is observed in liver and muscle of rats treated with streptozotocin. The association of Shc/Grb2 is also increased in both tissues following insulin treatment, These data suggest that while epinephrine preserves the insulin/induced phosphorylation of She and the mitogenic pathway stimulated by Shc-Grb2 association, treatment with streptozotocin leads to a tissue-specific increase in the activity of the initial step that ultimately results in the activation of the Shc/Grb2 mitogenic pathway.
dc.description14
dc.description3
dc.description295
dc.description302
dc.languageen
dc.publisherHumana Press Inc
dc.publisherTotowa
dc.publisherEUA
dc.relationEndocrine
dc.relationEndocrine
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectepinephrine
dc.subjectdiabetes mellitus
dc.subjectstreptozotocin
dc.subjectinsulin receptor substrate-1
dc.subjectShc
dc.subjectShc-Grb2 association
dc.subjectMitogenic Signal-transduction
dc.subjectReceptor Substrate Family
dc.subjectActivated Protein-kinase
dc.subjectPhosphatidylinositol 3-kinase
dc.subjectPhosphotyrosine Protein
dc.subjectGrowth-hormone
dc.subjectDiabetic Rats
dc.subjectDomain
dc.subjectIrs-1
dc.subjectCells
dc.titleRegulation of insulin-stimulated tyrosine phosphorylation of Shc and Shc/Grb2 association in liver, muscle, and adipose tissue of epinephrine- and streptozotocin-treated rats
dc.typeArtículos de revistas


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