Differential cytokine expressions affect the severity of peri-implant disease

dc.creatorDuarte, PM
dc.creatorde Mendonca, AC
dc.creatorMaximo, MBB
dc.creatorSantos, VR
dc.creatorBastos, MF
dc.creatorNociti, FH
dc.date2009
dc.dateMAY
dc.date2014-11-15T12:38:40Z
dc.date2015-11-26T16:11:13Z
dc.date2014-11-15T12:38:40Z
dc.date2015-11-26T16:11:13Z
dc.date.accessioned2018-03-28T22:59:42Z
dc.date.available2018-03-28T22:59:42Z
dc.identifierClinical Oral Implants Research. Wiley-blackwell Publishing, Inc, v. 20, n. 5, n. 514, n. 520, 2009.
dc.identifier0905-7161
dc.identifierWOS:000265145700012
dc.identifier10.1111/j.1600-0501.2008.01680.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61785
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61785
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61785
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267033
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionObjective: This study assessed gene expression by quantitative polymerase chain reaction of inflammatory-[interleukin (IL)-12, tumor necrosis factor-alpha (TNF-alpha), IL-4, and IL-10] and osteoclastogenesis-related factors [receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG)] in sites exhibiting different severities of peri-implant disease. Material and methods: Peri-implant soft tissue biopsies (n=48) were harvested from healthy implant (HI), mucositis (MC), initial peri-implantitis (IP) and severe peri-implantitis (SP) sites. Results: IL-12 and TNF-alpha mRNA levels were higher in SP, followed by IP and MC (P < 0.05). IL-4 was higher in HI, followed by MC, SP and IP (P < 0.05). IL-10 was the lowest in HI, while no differences were detected among the diseased groups (P=0.05). OPG mRNA levels were higher in HI, followed by IP, SP and MC, whereas RANKL was increased as the peri-implantitis severity increased (P < 0.05). The highest OPG/RANKL ratio was observed in HI and the lowest in SP (P < 0.01). Conclusion: These findings suggest that expressions of inflammatory- and osteoclastogenesis-related factors may play an important role in the onset and severity of the peri-implant diseases.
dc.description20
dc.description5
dc.description514
dc.description520
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [05/02561-3, 06/04604-4]
dc.descriptionCNPq [471282/2007-3, 303980/2007-9]
dc.languageen
dc.publisherWiley-blackwell Publishing, Inc
dc.publisherMalden
dc.publisherEUA
dc.relationClinical Oral Implants Research
dc.relationClin. Oral Implant. Res.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectcytokines
dc.subjectgene expression
dc.subjectmucositis
dc.subjectperi-implant diseases
dc.subjectperi-implantitis
dc.subjectNecrosis-factor-alpha
dc.subjectKappa-b Ligand
dc.subjectOsteoclast Differentiation
dc.subjectReceptor Activator
dc.subjectOsteoprotegerin Ligand
dc.subjectPeriodontal-disease
dc.subjectCrevicular Fluid
dc.subjectGene-expression
dc.subjectBone-resorption
dc.subjectImmune-response
dc.titleDifferential cytokine expressions affect the severity of peri-implant disease
dc.typeArtículos de revistas


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