dc.creatorMerzel, J
dc.creatorNovaes, PD
dc.date2006
dc.dateOCT
dc.date2014-11-15T10:32:32Z
dc.date2015-11-26T16:10:38Z
dc.date2014-11-15T10:32:32Z
dc.date2015-11-26T16:10:38Z
dc.date.accessioned2018-03-28T22:59:15Z
dc.date.available2018-03-28T22:59:15Z
dc.identifierArchives Of Oral Biology. Pergamon-elsevier Science Ltd, v. 51, n. 10, n. 825, n. 835, 2006.
dc.identifier0003-9969
dc.identifierWOS:000241292400001
dc.identifier10.1016/j.archoralbio.2006.03.010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61602
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61602
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61602
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266924
dc.descriptionThe resection of the labial half of the odontogenic organ of rat incisors resulted in the development of teeth without enamel. Ten out of 26 operated rats developed a functional dentin incisor, i.e. a continuously growing and erupting tooth. These teeth were a little shorter and much thinner than normal incisors. The dentin and pulp presented a normal structure. Periodontal Ligament and cement started to develop at the lingual face and gradually all tooth faces were invested by these tissues. The original socket space, to accommodate a thinner tooth, was narrowed by newly formed bone around the inner face of the socket. Eleven rats developed defective dentin incisors; these teeth showed signs of growth, however, their eruption was impaired. The operation failed in five rats. The odontogenic organ of the dentin incisor presented islands of epithelial cells at the labial aspect of a dense mass of mesenchyme cells. These islands, formed by densely packed, dark-staining cells encircling a few pate-staining cells, merged gradually, forming a root sheath and a cervical loop limiting a Long apical foramen. The bulk of the bulbous part (apical bud) was absent; thus, there was no differentiation of ameloblasts and of the crown-analogue part of the incisor. The growth and eruptive behaviour of the dentin incisor, similar to that of a normal incisor, indicates that it has to bear a stem cell niche to retain its regenerative capacity. As in the apical bud, this niche is apparently located at the stellate reticulum of the cervical loop. The putative molecular mechanisms related to either the maintenance of the stem cell niche or the differentiation of the enamel organ and the root sheath are discussed. These data and our results, showing the development of a functional dentin incisor, suggest that the root-analogue part of the rodent incisor is an anatomic-physiological entity. (c) 2006 Elsevier Ltd. All rights reserved.
dc.description51
dc.description10
dc.description825
dc.description835
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationArchives Of Oral Biology
dc.relationArch. Oral Biol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectrat dentin incisor
dc.subjectpartial root resection
dc.subjecttooth stem cell niches
dc.subjectStem-cell Niche
dc.subjectTooth Eruption
dc.subjectUnimpeded Eruption
dc.subjectRoot Transection
dc.subjectMouse Incisors
dc.subjectAlveolar Bone
dc.subjectEnamel Aspect
dc.subjectPeriodontium
dc.subjectTeeth
dc.subjectFollicle
dc.titleDevelopment of functional dentin incisors after a partial resection of the odontogenic organ of rat incisors
dc.typeArtículos de revistas


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