Diagnosis of 5 alpha-reductase type 2 deficiency: Contribution of anti-Mullerian hormone evaluation

dc.creatorStuchi-Perez, EG
dc.creatorHackel, C
dc.creatorOliveira, LEC
dc.creatorFerraz, LFC
dc.creatorOliveira, LC
dc.creatorNunes-Silva, D
dc.creatorToralles, MB
dc.creatorSteinmetz, L
dc.creatorDamiani, D
dc.creatorMaciel-Guerra, AT
dc.creatorGuerra, G
dc.date2005
dc.date2014-11-15T09:54:29Z
dc.date2015-11-26T16:10:30Z
dc.date2014-11-15T09:54:29Z
dc.date2015-11-26T16:10:30Z
dc.date.accessioned2018-03-28T22:59:07Z
dc.date.available2018-03-28T22:59:07Z
dc.identifierJournal Of Pediatric Endocrinology & Metabolism. Freund Publishing House Ltd, v. 18, n. 12, n. 1383, n. 1389, 2005.
dc.identifier0334-018X
dc.identifierWOS:000235123800004
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61668
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61668
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61668
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266888
dc.descriptionAim: To evaluate anti-Mullerian hormone (AMH) levels in patients with clinical and molecular diagnosis of 5 alpha-reductase 2 deficiency. Patients and Methods: Data from 14 patients whose age ranged from 21 days to 29 years were analyzed according to age and pubertal stage. Sexual ambiguity was rated as Prader III in 11 patients. LH, FSH, testosterone (T), dihydrotestosterone (DHT) and AMH serum levels were measured in all but two patients, who had been previously submitted to gonadectomy; T and DHT were also measured in 20 age-matched controls. Results: Gonadotropin levels were normal in all but one patient who retained gonads (six of whom had reached puberty) and T/DHT ratio was elevated in all patients when compared to controls. All prepubertal patients had AMH levels < -1 SD for age, while most pubertal patients had AMH levels compatible with pubertal stage. Conclusions: Prepubertal patients with 5 alpha-reductase 2 deficiency have AMH values in the lower part of the normal range. These data indicate that T does not need to be converted to DHT to inhibit AMH secretion by Sertoli cells.
dc.descriptiono TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.
dc.description18
dc.description12
dc.description1383
dc.description1389
dc.languageen
dc.publisherFreund Publishing House Ltd
dc.publisherTel Aviv
dc.publisherIsrael
dc.relationJournal Of Pediatric Endocrinology & Metabolism
dc.relationJ. Pediatr. Endocrinol. Metab.
dc.rightsembargo
dc.sourceWeb of Science
dc.subjectandrogen insensitivity syndrome
dc.subjectMullerian inhibiting hormone
dc.subjectdihydrotestosterone
dc.subjectpseudohermaphroditism
dc.subjecttestosterone
dc.subject5 alpha-reductase
dc.subjectSteroid 5alpha-reductase Deficiency
dc.subjectInhibiting Substance
dc.subjectMale Pseudohermaphroditism
dc.subjectAntimullerian Hormone
dc.subjectAmbiguous Genitalia
dc.subjectGender Identity
dc.subjectLeydig-cells
dc.subjectGene
dc.subjectAndrogens
dc.subjectChildren
dc.titleDiagnosis of 5 alpha-reductase type 2 deficiency: Contribution of anti-Mullerian hormone evaluation
dc.typeArtículos de revistas


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