Texture analysis of the epidermis based on fast Fourier transformation in Sjogren-Larsson syndrome

dc.creatorAuada, MP
dc.creatorAdam, RL
dc.creatorLeite, NJ
dc.creatorPuzzi, MB
dc.creatorCintra, ML
dc.creatorRizzo, WB
dc.creatorMetze, K
dc.date2006
dc.dateAUG
dc.date2014-11-15T08:34:22Z
dc.date2015-11-26T16:10:12Z
dc.date2014-11-15T08:34:22Z
dc.date2015-11-26T16:10:12Z
dc.date.accessioned2018-03-28T22:58:49Z
dc.date.available2018-03-28T22:58:49Z
dc.identifierAnalytical And Quantitative Cytology And Histology. Sci Printers & Publ Inc, v. 28, n. 4, n. 219, n. 227, 2006.
dc.identifier0884-6812
dc.identifierWOS:000239524400006
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78655
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/78655
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78655
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266813
dc.descriptionOBJECTIVE: To investigate whether image analysis of routine hematoxylin-eosin (H-E) skin sections using fast Fourier transformation (FFT) could detect structural alterations in patients with Sjogren-Larsson syndrome (SLS) diagnosed by molecular biology. STUDY DESIGN: Skin punch biopsies of 9 patients with SLS and 17 healthy volunteers were obtained. Digital images of routine histologic sections were taken, and their gray scale luminance was analyzed by FFT. The inertia values were determined for different ranges of the spatial frequencies in the vertical and horizontal direction. To get an estimation of anisotropy, we calculated the resultant vector of the designated frequency ranges. RESULTS: In the prickle cell layer, SLS patients showed more intense amplitudes in spatial structures with periods between 1.2 and 3.6 mu m in the vertical direction, which correlated in part with accentuated nuclei and nucleoli and perinucleolar halos in the H-E sections. In a linear discriminant analysis, the variables derived from the FFT images correctly discriminated 84.6% of the patients. Texture features derived from the gray level co-occurrence matrix were not able to separate the groups. CONCLUSION: Exploratory texture analysis by FFT was able to detect discrete alterations in the prickle cell layer in routine light microscopy slides of SLS patients. The structural changes identified by FFT may be related to abnormal cellular components associated with aberrant lipid metabolism.
dc.description28
dc.description4
dc.description219
dc.description227
dc.languageen
dc.publisherSci Printers & Publ Inc
dc.publisherSt Louis
dc.publisherEUA
dc.relationAnalytical And Quantitative Cytology And Histology
dc.relationAnal. Quant. Cytol. Histol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectepidermis
dc.subjectichthyosis
dc.subjectkaryometry
dc.subjectmorphometry
dc.subjectnucleus
dc.subjectnucleolus
dc.subjectpathology
dc.subjectquantitative
dc.subjectCultured Fibroblasts
dc.subjectChromatin Texture
dc.subjectImage-analysis
dc.subjectFatty Alcohol
dc.subjectSkin
dc.subjectMorphometry
dc.subjectMucosa
dc.subjectOxidoreductase
dc.subjectMicroscopy
dc.subjectMorphology
dc.titleTexture analysis of the epidermis based on fast Fourier transformation in Sjogren-Larsson syndrome
dc.typeArtículos de revistas


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