A novel FY allele in Brazilians

dc.creatorCastilho, L
dc.creatorRios, M
dc.creatorPellegrino, J
dc.creatorSaad, STO
dc.creatorCosta, FF
dc.creatorReid, ME
dc.date2004
dc.dateOCT
dc.date2014-11-15T08:06:06Z
dc.date2015-11-26T16:10:07Z
dc.date2014-11-15T08:06:06Z
dc.date2015-11-26T16:10:07Z
dc.date.accessioned2018-03-28T22:58:44Z
dc.date.available2018-03-28T22:58:44Z
dc.identifierVox Sanguinis. Blackwell Publishing Ltd, v. 87, n. 3, n. 190, n. 195, 2004.
dc.identifier0042-9007
dc.identifierWOS:000224989600008
dc.identifier10.1111/j.1423-0410.2004.00554.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76543
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/76543
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76543
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266789
dc.descriptionThe GATA box single nucleotide polymorphism (SNP) at position -33 (T>C) in Blacks silences the expression of FY*B in erythrocytes, and the substitution 265 C>T, together with 298 G>A, weakens the Fy(b) antigen (Fy(x)). Individuals with these phenotypes/genotypes who receive Fy(b+) blood are unlikely to be alloimmunized to Fy(b) because, in the presence of 265 T, the Fyb antigen is expressed, and in the case of -33 C, other tissues express Duffy protein and probably the Fy(b) antigen. We studied samples from 361 blood donors (182 of African ancestry and 179 of Caucasian ancestry) by haem agglutination and polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP). Forty Caucasian and 130 donors of African ancestry were serologically Fy(b-); among these, the majority of the donors of African ancestry had FY*B with the GATA SNP, while the majority of Caucasians typing Fy(b-) had FY*B with 265 T/298 A SNPs. Six of the Fy(b-) donors (three Africans and three Caucasians) had both GATA and 265/298 SNPs, and six donors of Caucasian ancestry apparently had a GATA SNP. Samples from two donors - one African and one Caucasian with an unusual MspA I I-RFLP pattern - were sequenced and found to have a novel SNP (145 G>T) co-existent with 265 C>T and 298 G>A SNPs. These findings highlight the importance of establishing the incidence and nature of molecular events that impact on Duffy expression in different populations.
dc.description87
dc.description3
dc.description190
dc.description195
dc.languageen
dc.publisherBlackwell Publishing Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationVox Sanguinis
dc.relationVox Sang.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectBrazilians
dc.subjectDuffy blood group system
dc.subjectDuffy prevalence in Brazilians
dc.subjectFY gene
dc.subjectFy(x)
dc.subjectprevalence of Duffy gene
dc.subjectDuffy-negative Individuals
dc.subjectPlasmodium-vivax
dc.subjectCoding Sequence
dc.subjectGene
dc.subjectExpression
dc.subjectPhenotype
dc.subjectGlycoprotein
dc.subjectReceptor
dc.subjectAntigen/receptor
dc.subjectIdentification
dc.titleA novel FY allele in Brazilians
dc.typeArtículos de revistas


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