Molecular heterogeneity of the A(3) subgroup

dc.creatorBarjas-Castro, ML
dc.creatorCarvalho, MH
dc.creatorLocatelli, MF
dc.creatorBordin, S
dc.creatorSaad, STO
dc.date2000
dc.dateAPR
dc.date2014-12-02T16:24:47Z
dc.date2015-11-26T16:09:53Z
dc.date2014-12-02T16:24:47Z
dc.date2015-11-26T16:09:53Z
dc.date.accessioned2018-03-28T22:58:29Z
dc.date.available2018-03-28T22:58:29Z
dc.identifierClinical And Laboratory Haematology. Blackwell Science Ltd, v. 22, n. 2, n. 73, n. 78, 2000.
dc.identifier0141-9854
dc.identifierWOS:000087420200002
dc.identifier10.1046/j.1365-2257.2000.00289.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57782
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57782
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57782
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266732
dc.descriptionThe molecular characterization of the subgroup A(3) remains unclear. Four unrelated A(3) blood donors were studied. Family studies were possible in three of them. The A(3) subgroup was defined by immunohaematological evaluation with four different commercially available serums, Exons VI and VII of the ABO gene, responsible for 91% of the catalytic active part of the glycosyltransferase, were amplified and subjected to direct sequencing, The results in all samples showed heterozygosity for the G261 deletion, In the A(3) allele, the following associations were found: C467T mutation and 1060C deletion in one A(3) blood donor and in another G829A and 1060C. In one case, only the 1060C deletion was demonstrated in the A(3) allele. One blood donor presented the T646A and the G829A mutations in homozygosity. It was concluded that the Ag blood group is very heterogeneous at the molecular level.
dc.description22
dc.description2
dc.description73
dc.description78
dc.languageen
dc.publisherBlackwell Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationClinical And Laboratory Haematology
dc.relationClin. Lab. Haematol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectA subgroup
dc.subjectABO
dc.subjectantigens
dc.subjectblood groups
dc.subjectgenotyping
dc.subjectBlood-group System
dc.subjectGroup Abo Locus
dc.subjectGenetic-analysis
dc.subjectGroup-a
dc.subjectO-allele
dc.subjectRecombination
dc.subjectErythrocytes
dc.subjectExpression
dc.subjectPhenotype
dc.subjectAntigens
dc.titleMolecular heterogeneity of the A(3) subgroup
dc.typeArtículos de revistas


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