Development of a behavioral model of TMJ pain in rats: the TMJ formalin test

dc.creatorRoveroni, RC
dc.creatorParada, CA
dc.creatorCecilia, M
dc.creatorVeiga, FA
dc.creatorTambeli, CH
dc.date2001
dc.dateNOV
dc.date2014-11-15T06:56:16Z
dc.date2015-11-26T16:09:45Z
dc.date2014-11-15T06:56:16Z
dc.date2015-11-26T16:09:45Z
dc.date.accessioned2018-03-28T22:58:22Z
dc.date.available2018-03-28T22:58:22Z
dc.identifierPain. Elsevier Science Bv, v. 94, n. 2, n. 185, n. 191, 2001.
dc.identifier0304-3959
dc.identifierWOS:000172398700010
dc.identifier10.1016/S0304-3959(01)00357-8
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61541
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61541
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61541
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266699
dc.descriptionTemporomandibular joint (TMJ) pain conditions are poorly understood. Since formalin is a noxious stimulus widely used in animal behavioral experiments for studying pain mechanisms, the aim of this study was to develop a behavioral model to study the TMJ pain conditions by characterizing the nociceptive behavioral responses induced by the injection of formalin into the TMJ region of rats. NaCl (0.9%) or different concentrations of formalin (0.5, 1.5, 2.5 or 5%) were administrated into the TMJ region. The form alin-induced behavioral responses characterized by moving the mandible, rubbing the orofacial region and flinching the head quickly were quantified for 45 mm. The TMJ injection of formalin significantly increased the asymmetrical orofacial rubbing and head flinching behaviors, but not the movement of the mandible with concentrations of 1.5% and above (P < 0.05, Dunn's test) when compared with the NaCl (0.9%) injection. These responses were significantly reduced (P < 0.05, Mann-Whitney test) by the co-application of lidocaine N-ethyl bromide quaternary salt, QX-314 (2%), and by the administration of intraperitoneal morphine (4 mg/kg) 30 min prior to the TMJ formalin injection. This study demonstrates that the injection of formalin into the TMJ region of rats produces quantitative nociceptive behaviors constituting a novel behavioral model for TMJ pain. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.
dc.description94
dc.description2
dc.description185
dc.description191
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationPain
dc.relationPain
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjecttemporomandibular joint
dc.subjectformalin test
dc.subjectnociception
dc.subjectmorphine
dc.subjectQX-314
dc.subjectrat
dc.subjectStem Nociceptive Neurons
dc.subjectSubcutaneous Formalin
dc.subjectModulation
dc.subjectMechanisms
dc.subjectResponses
dc.subjectTissues
dc.subjectNerve
dc.titleDevelopment of a behavioral model of TMJ pain in rats: the TMJ formalin test
dc.typeArtículos de revistas


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