Synthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics

dc.creatorLeite, ACL
dc.creatorVieira, RF
dc.creatorde Faria, AR
dc.creatorWanderley, AG
dc.creatorAfiatpour, P
dc.creatorXimenes, ECPA
dc.creatorSrivastava, RM
dc.creatorde Oliveira, CF
dc.creatorMedeiros, MV
dc.creatorAntunes, E
dc.creatorBrondani, DJ
dc.date2000
dc.dateNOV-DEC
dc.date2014-12-02T16:24:43Z
dc.date2015-11-26T16:09:35Z
dc.date2014-12-02T16:24:43Z
dc.date2015-11-26T16:09:35Z
dc.date.accessioned2018-03-28T22:58:12Z
dc.date.available2018-03-28T22:58:12Z
dc.identifierFarmaco. Elsevier Science Sa, v. 55, n. 41984, n. 719, n. 724, 2000.
dc.identifier0014-827X
dc.identifierWOS:000166208000010
dc.identifier10.1016/S0014-827X(00)00099-9
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79272
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/79272
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79272
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266660
dc.descriptionA new series of 1,2,4-oxadizoles 6a-g have been synthesised in good yields using the peptide synthesis strategy. The prepared compounds were tested for anti-inflammatory and antimicrobial activities. The anti-inflammatory activities were determined in the rat paw oedema induced by carrageenin. Compounds 6a, c, f and g (i.v.) significantly inhibited the rat paw oedema induced by carrageenin depending upon the dose employed. The compounds were also evaluated for their in vitro antimicrobial activity. Some compounds were found to have significant activity against Gram positive and Gram negative microorganisms. (C) 2000 Elsevier Science S.A. All rights reserved.
dc.description55
dc.description41984
dc.description719
dc.description724
dc.languageen
dc.publisherElsevier Science Sa
dc.publisherLausanne
dc.publisherSuíça
dc.relationFarmaco
dc.relationFarmaco
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectanti-inflammatory activity
dc.subjectpotential antimicrobial agents
dc.subject1,2,4-oxadiazoles
dc.subjectpeptidomimetics
dc.subjectpeptide synthesis
dc.subject3-<3-(aryl)-1,2,4-oxadiazol-5-yl> Propionic Acids
dc.subjectInhibitors
dc.titleSynthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics
dc.typeArtículos de revistas


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