Interferon beta and glatiramer acetate induce proliferation of Schwann cells in vitro

dc.creatorZanon, RG
dc.creatorPierucci, A
dc.creatorOliveira, ALR
dc.date2009
dc.date2014-07-30T14:33:57Z
dc.date2015-11-26T16:09:14Z
dc.date2014-07-30T14:33:57Z
dc.date2015-11-26T16:09:14Z
dc.date.accessioned2018-03-28T22:57:49Z
dc.date.available2018-03-28T22:57:49Z
dc.identifierActa Neurobiologiae Experimentalis. Nencki Inst Experimental Biology, v. 69, n. 1, n. 146, n. 152, 2009.
dc.identifier0065-1400
dc.identifierWOS:000264887000014
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60430
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60430
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266564
dc.descriptionTechniques as well as substances capable of stimulating cultured Schwann cell (SC) proliferation are needed for future therapeutical applications. In this work, the effects of interferon beta (IFNbeta) and glatiramer acetate (GA) on SC cultures were tested, with interest on the growth curve and potential proliferative effects. Primary cultures were prepared from the sciatic nerves of neonatal rats and seeded onto culture plates. Such cells were then subjected to treatment with different doses of IFN beta (100, 500 and 1000 IU/ml) and of GA (1.2, 2.5 and 5.0 mu g/ml) for five consecutive days. S 1000 and DAPI double labeling was used in order to confirm the purity of the cultures. Both treatment with IFN and GA resulted in an increased number of cultured SCs. However, only IFN beta induced a statistically significant proliferative outcome. Such results indicate that addition of IFN beta to the culture medium is efficient in order to improve SC proliferation in vitro.
dc.description69
dc.description1
dc.description146
dc.description152
dc.languageen
dc.publisherNencki Inst Experimental Biology
dc.publisherWarsaw
dc.publisherPolónia
dc.relationActa Neurobiologiae Experimentalis
dc.relationActa Neurobiol. Exp.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectSchwann cell
dc.subjectnerve regeneration
dc.subjectinterferon beta
dc.subjectglatiramer acetate
dc.subjectcell culture
dc.subjectPeripheral-nerve Regeneration
dc.subjectSpinal-cord
dc.subjectMultiple-sclerosis
dc.subjectSystem
dc.subjectRepair
dc.subjectTransplantation
dc.subjectExpression
dc.subjectMechanism
dc.subjectCultures
dc.titleInterferon beta and glatiramer acetate induce proliferation of Schwann cells in vitro
dc.typeArtículos de revistas


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