Carbohydrate-energy restriction may protect the rat brain against oxidative damage and improve physical performance

dc.creatorde Oliveira, SL
dc.creatorDiniz, DB
dc.creatorAmaya-Farfan, J
dc.date2003
dc.dateJAN
dc.date2014-11-14T20:53:00Z
dc.date2015-11-26T16:08:28Z
dc.date2014-11-14T20:53:00Z
dc.date2015-11-26T16:08:28Z
dc.date.accessioned2018-03-28T22:57:02Z
dc.date.available2018-03-28T22:57:02Z
dc.identifierBritish Journal Of Nutrition. C A B I Publishing, v. 89, n. 1, n. 89, n. 96, 2003.
dc.identifier0007-1145
dc.identifierWOS:000180648600011
dc.identifier10.1079/BJN2002749
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63143
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/63143
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63143
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266368
dc.descriptionChronic energy restriction, alpha-tocopherol supplementation and their interaction with exhaustive exercise were investigated. Eleven-week-old male Wistar rats (n 6 x 10) were fed either a control (C), a 30 % carbohydrate-energy-restricted control (R) or an alpha-tocopherol-supplemented (S) diet for 5 months. The animals in each diet were divided into exercised (E) and non-exercised (NE) groups. Before killing, the exercised rats were required to run to exhaustion (39 (SE 6), 69 (SE, 11) and 18 (SE 2) min for the C, R and S groups, respectively). Lipid peroxidation (thiobarbituric acid-reactive substances; TBARS), protein damage (reactive carbonyls) and alpha-tocopherol were determined in gastrocnemius, liver, brain and/or plasma. There was no difference in lipid peroxidation between the R and C groups, but in liver and muscle peroxidation appeared significantly lower in the S than the other two diets. TBARS in the brain were similar in all groups. On the other hand, reactive carbonyls showed that both the R and S diets reduced protein damage in the brain, while exhaustive exercise increased it. For liver and muscle, however, reactive carbonyl levels were similar in all groups. alpha-Tocopherol supplementation increased the vitamin concentrations in liver, muscle and plasma, but exercise decreased them in plasma and brain. Carbohydrate-energy restriction increased (P=0.0025) resistance to exhaustive exercise considerably without depleting stores of alpha-tocopherol or exacerbating oxidative damage in monitored tissues. It is concluded that while exhaustive exercise promotes a tissue-specific oxidative damage detectable only in brain proteins, both experimental diets tended to ameliorate this condition.
dc.descriptiono TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.
dc.description89
dc.description1
dc.description89
dc.description96
dc.languageen
dc.publisherC A B I Publishing
dc.publisherWallingford
dc.publisherInglaterra
dc.relationBritish Journal Of Nutrition
dc.relationBr. J. Nutr.
dc.rightsembargo
dc.sourceWeb of Science
dc.subjectenergy restriction
dc.subjectvitamin E
dc.subjectoxidative stress
dc.subjectexercise
dc.subjectVitamin-e
dc.subjectLipid-peroxidation
dc.subjectDietary Restriction
dc.subjectAntioxidant Status
dc.subjectSkeletal-muscle
dc.subjectExercised Rats
dc.subjectMembrane Fluidity
dc.subjectAlpha-tocopherol
dc.subjectFood Restriction
dc.subjectDna-damage
dc.titleCarbohydrate-energy restriction may protect the rat brain against oxidative damage and improve physical performance
dc.typeArtículos de revistas


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