Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression

dc.creatorAltemani, A
dc.creatorMartins, MT
dc.creatorFreitas, L
dc.creatorSoares, F
dc.creatorAraujo, NS
dc.creatorAraujo, VC
dc.date2005
dc.dateJUN
dc.date2014-11-14T19:18:50Z
dc.date2015-11-26T16:07:57Z
dc.date2014-11-14T19:18:50Z
dc.date2015-11-26T16:07:57Z
dc.date.accessioned2018-03-28T22:56:37Z
dc.date.available2018-03-28T22:56:37Z
dc.identifierHistopathology. Blackwell Publishing, v. 46, n. 6, n. 635, n. 641, 2005.
dc.identifier0309-0167
dc.identifierWOS:000229780800004
dc.identifier10.1111/j.1365-2559.2005.02157.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63166
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/63166
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63166
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266263
dc.descriptionAims: To characterize the cellular component in pleomorphic adenoma (PA) that undergoes malignant transformation in carcinoma ex pleomorphic adenoma (CXPA). Methods and results: A panel of antibodies against cytoskeletal proteins was applied in 16 cases of CXPA: intracapsular carcinoma (five cases), minimally invasive (four cases) and frankly invasive (seven cases). The CXPAs were classified into two main groups according to their predominant cellular component as detected by the panel of antibodies: (i) carcinomas with only epithelial differentiation (75% of the cases). and (ii) carcinomas with a myoepithelial component (25%). CXPA with only epithelial differentiation showed two types of malignant areas in the part of the tumour that was confined by the PA capsule: (i) intraductal carcinoma areas characterized by ductal structures containing both benign myoepithelial cells positive for alpha-smooth muscle actin (alpha-SMA), vimentin and cytokeratin (CK)14 and proliferating atypical luminal cells reactive for CK7, CKS and CK19, and (ii) carcinoma areas composed only of epithelial cells reactive for CK7, CK8 and CK19. In the latter, the cells presented morphological and immunohistochemical characteristics similar to those found in areas of invasive carcinoma outside the PA capsule. CXPAs with a myoepithelial component were composed mainly or exclusively of cells that expressed vimentin and alpha-SMA. In this group, ductal structures reminiscent of PA filled by malignant cells were not identified. Conclusion: Most CXPAs consist only of epithelial cells that have an immunoprofile comparable to ductal luminal cells of PA. These malignant luminal cells arise in the duct-like structures as intraductal carcinoma and probably only at this early stage of development should the lesion be considered as a non-invasive carcinoma.
dc.description46
dc.description6
dc.description635
dc.description641
dc.languageen
dc.publisherBlackwell Publishing
dc.publisherOxford
dc.publisherInglaterra
dc.relationHistopathology
dc.relationHistopathology
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectcarcinoma
dc.subjectimmunoprofile
dc.subjectpleomorphic adenoma
dc.subjectMalignant Mixed Tumors
dc.subjectSalivary-glands
dc.subjectExpression
dc.titleCarcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression
dc.typeArtículos de revistas


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