Imbalances in serum angiopoietin concentrations are early predictors of septic shock development in patients with post chemotherapy febrile neutropenia

dc.creatorAlves, BE
dc.creatorMontalvao, SAL
dc.creatorAranha, FJP
dc.creatorSiegl, TFG
dc.creatorSouza, CA
dc.creatorLorand-Metze, I
dc.creatorAnnichino-Bizzacchi, JM
dc.creatorDe Paula, EV
dc.date2010
dc.dateMAY 28
dc.date2014-11-14T16:37:37Z
dc.date2015-11-26T16:07:31Z
dc.date2014-11-14T16:37:37Z
dc.date2015-11-26T16:07:31Z
dc.date.accessioned2018-03-28T22:56:10Z
dc.date.available2018-03-28T22:56:10Z
dc.identifierBmc Infectious Diseases. Biomed Central Ltd, v. 10, 2010.
dc.identifier1471-2334
dc.identifierWOS:000279895900005
dc.identifier10.1186/1471-2334-10-143
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69246
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69246
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69246
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266150
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionBackground: Febrile neutropenia carries a high risk of sepsis complications, and the identification of biomarkers capable to identify high risk patients is a great challenge. Angiopoietins (Ang -) are cytokines involved in the control microvascular permeability. It is accepted that Ang-1 expression maintains endothelial barrier integrity, and that Ang-2 acts as an antagonizing cytokine with barrier-disrupting functions in inflammatory situations. Ang-2 levels have been recently correlated with sepsis mortality in intensive care units. Methods: We prospectively evaluated concentrations of Ang-1 and Ang-2 at different time-points during febrile neutropenia, and explored the diagnostic accuracy of these mediators as potential predictors of poor outcome in this clinical setting before the development of sepsis complications. Results: Patients that evolved with septic shock (n = 10) presented higher levels of Ang-2 measured 48 hours after fever onset, and of the Ang-2/Ang-1 ratio at the time of fever onset compared to patients with non-complicated sepsis (n = 31). These levels correlated with sepsis severity scores. Conclusions: Our data suggest that imbalances in the concentrations of Ang-1 and Ang-2 are independent and early markers of the risk of developing septic shock and of sepsis mortality in febrile neutropenia, and larger studies are warranted to validate their clinical usefulness. Therapeutic strategies that manipulate this Ang-2/Ang-1 imbalance can potentially offer new and promising treatments for sepsis in febrile neutropenia.
dc.description10
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherBiomed Central Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationBmc Infectious Diseases
dc.relationBMC Infect. Dis.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectExcess Circulating Angiopoietin-2
dc.subjectCritically-ill Patients
dc.subjectSevere Sepsis
dc.subjectMultinational-association
dc.subjectSupportive-care
dc.subjectOrgan Failure
dc.subjectRisk-index
dc.subjectMortality
dc.subjectCancer
dc.subjectDysfunction
dc.titleImbalances in serum angiopoietin concentrations are early predictors of septic shock development in patients with post chemotherapy febrile neutropenia
dc.typeArtículos de revistas


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