Mesenteric adipose tissue alterations resulting from experimental, reactivated colitis

dc.creatorGambero, A
dc.creatorMarostica, M
dc.creatorSaad, MJA
dc.creatorPedrazzoli, J
dc.date2007
dc.dateNOV
dc.date2014-11-17T02:02:03Z
dc.date2015-11-26T16:07:17Z
dc.date2014-11-17T02:02:03Z
dc.date2015-11-26T16:07:17Z
dc.date.accessioned2018-03-28T22:55:59Z
dc.date.available2018-03-28T22:55:59Z
dc.identifierInflammatory Bowel Diseases. Wiley-blackwell, v. 13, n. 11, n. 1357, n. 1364, 2007.
dc.identifier1078-0998
dc.identifierWOS:000250814400005
dc.identifier10.1002/ibd.20222
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/53611
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/53611
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/53611
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266098
dc.descriptionBackground: Adipose tissue secretes a large number of hormones that act either locally or at distant sites, modulating immune responses, inflammation, and many endocrine and metabolic functions. Abnormalities of fat in the mesentery have been long recognized in surgical specimens as characteristic features of Crohn's disease; however, the importance of this in chronic inflammatory disease is unknown. Additionally,, adipocytes in depots that enclose lymph nodes or other dense masses of lymphoid tissue have many site-specific physiological properties. Methods: In this study, the alterations of mesenteric and perinodal mesenteric adipose tissue during experimental colitis, induced by repeated intracolonic trinitrobenzene sulfonic acid instillations, were evaluated, focusing on morphological and activity alterations and the adipocytokine production profile. Results: After a 35-day protocol, the colitis animals presented greater mesenteric fat masses despite their lower body weights. Another adipose tissue depot,' epididymal adipose tissue, was also evaluated and no change in mass was observed. The mesenteric adipocyte from colitis animals had a reduced diameter, normal PPAR-gamma-2 expression, and higher basal lipolysis and TNF-alpha production when compared to normal rats. Perinodal mesenteric adipocytes present normal diameters, downregulated levels of PPAR-gamma-2, higher basal lipolysis and TNF-alpha, and leptin and adiponectin production. Conclusions: The findings suggest that mesenteric adipose tissue has a site-specific response during experimental inflammation, where perinodal adipose tissue retains the ability to produce different adipocytokines. These substances may interfere in many lymph node aspects, while mesenteric adipose tissue produces substances that could contribute directly to aggravate the inflammatory process.
dc.description13
dc.description11
dc.description1357
dc.description1364
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationInflammatory Bowel Diseases
dc.relationInflamm. Bowel Dis.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectleptin
dc.subjectadiponectin
dc.subjectTNF-alpha
dc.subjectperinodal adipose tissue
dc.subjectmesenteric adipose tissue
dc.subjectInflammatory-bowel-disease
dc.subjectNecrosis-factor-alpha
dc.subjectCrohns-disease
dc.subjectInsulin-resistance
dc.subjectDendritic Cells
dc.subjectLymph-nodes
dc.subjectTnf-alpha
dc.subjectLeptin
dc.subjectAdiponectin
dc.subjectObesity
dc.titleMesenteric adipose tissue alterations resulting from experimental, reactivated colitis
dc.typeArtículos de revistas


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