Natural killer cell activity, lymphocyte proliferation, and cytokine profile in tumor-bearing mice treated with MAPA, a magnesium aggregated polymer from Aspergillus oryzae

dc.creatorJusto, GZ
dc.creatorDuran, N
dc.creatorQueiroz, MLS
dc.date2003
dc.date2014-11-14T15:01:41Z
dc.date2015-11-26T16:07:09Z
dc.date2014-11-14T15:01:41Z
dc.date2015-11-26T16:07:09Z
dc.date.accessioned2018-03-28T22:55:51Z
dc.date.available2018-03-28T22:55:51Z
dc.identifierImmunopharmacology And Immunotoxicology. Marcel Dekker Inc, v. 25, n. 3, n. 305, n. 319, 2003.
dc.identifier0892-3973
dc.identifierWOS:000185715900002
dc.identifier10.1081/IPH.120024499
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63435
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/63435
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63435
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266065
dc.descriptionThe present study examined the effects of MAPA, an antitumor aggregated polymer of protein magnesium ammonium phospholinoleate-palmitoleate anhydride, isolated from Aspergillus oryzae, on concanavalin A (Con A)-induced spleen cell proliferation, cytokine production and on natural killer (NK) cell activity in Ehrlich ascites tumor-bearing mice. The Ehrlich ascites tumor (EAT) growth led to diminished mitogen-induced expansion of spleen cell populations and total NK activity. This was accompanied by striking spleen enlargement, with a marked increase in total cell counts. Moreover, a substantial enhancement in IL-10 levels, paralleled by a significant decrease in IL-2 was observed, while production of IL-4 and interferon-gamma (IFN-gamma) was not altered. Treatment of mice with 5 mg/kg MAPA for 7 days promoted spleen cell proliferation, IL-2 production and NK cell activity regardless of tumor outgrowth. In addition, MAPA treatment markedly enhanced IFN-gamma levels and reduced IL-10 production relative to EAT mice. A 35% reduction in splenomegaly with normal number of nucleated cells was also found. Altogether, our results suggest that MAPA directly and/or indirectly modulates immune cell activity, and probably disengages tumor-induced suppression of these responses. Clearly, MAPA has an impact and may delay tumor outgrowth through immunotherapeutic mechanisms.
dc.description25
dc.description3
dc.description305
dc.description319
dc.languageen
dc.publisherMarcel Dekker Inc
dc.publisherNew York
dc.publisherEUA
dc.relationImmunopharmacology And Immunotoxicology
dc.relationImmunopharmacol. Immunotoxicol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectEhrlich tumor
dc.subjectNK cell activity
dc.subjectIL-2
dc.subjectIFN-gamma IL-10
dc.subjectIL-4
dc.subjectMAPA
dc.subjectproteic aggregated polymer of magnesium ammonium phospholinoleate-palmitoleate
dc.subjectanhydride
dc.subjectT-cells
dc.subjectEhrlich Tumor
dc.subjectGamma Production
dc.subjectDown-regulation
dc.subjectIfn-gamma
dc.subjectInterleukin-2
dc.subjectInterferon
dc.subjectGrowth
dc.subjectIl-10
dc.subjectExpression
dc.titleNatural killer cell activity, lymphocyte proliferation, and cytokine profile in tumor-bearing mice treated with MAPA, a magnesium aggregated polymer from Aspergillus oryzae
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución