The intestinal permeation of didanosine from granules containing microspheres using the everted gut sac model

dc.creatorda Silva, CF
dc.creatorSeverino, P
dc.creatorMartins, F
dc.creatorChaud, MV
dc.creatorSantana, MHA
dc.date2009
dc.date2014-11-14T13:19:43Z
dc.date2015-11-26T16:06:39Z
dc.date2014-11-14T13:19:43Z
dc.date2015-11-26T16:06:39Z
dc.date.accessioned2018-03-28T22:55:28Z
dc.date.available2018-03-28T22:55:28Z
dc.identifierJournal Of Microencapsulation. Taylor & Francis Ltd, v. 26, n. 6, n. 523, n. 528, 2009.
dc.identifier0265-2048
dc.identifierWOS:000270687200007
dc.identifier10.1080/02652040802466691
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73559
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/73559
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73559
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265968
dc.descriptionThe aim of this research is to evaluate the intestinal permeation of a new formulation (NF) for the anti-retroviral didanosine (ddI) drug, using the everted gut sac model. The NF is composed by granules containing ddI incorporated in chitosan microspheres, plus free chitosan as an excipient. The permeation was evaluated across the three intestinal segments of adult male Wistar rats. The performance of ddI permeation from the NF was compared to the same granules without free chitosan and to buffered ddI tablets as control. The permeations across duodenum were higher than across jejune and ileum. The ddI from NF presented higher permeation and a crescent-shaped profile in duodenum compared to the other formulations. Such effects are provided by the superior mucoadhesiveness to the intestinal membrane and potentialize sustained release properties for NF. These results lead one to consider the novel formulation to be promising for ddI administration by oral route.
dc.description26
dc.description6
dc.description523
dc.description528
dc.languageen
dc.publisherTaylor & Francis Ltd
dc.publisherAbingdon
dc.publisherInglaterra
dc.relationJournal Of Microencapsulation
dc.relationJ. Microencapsul.
dc.rightsfechado
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.sourceWeb of Science
dc.subjectDidanosine
dc.subjectchitosan microspheres
dc.subjectgranules
dc.subjecteverted gut sac model
dc.subjectintestinal absorption
dc.subjectOral Absorption
dc.subjectIn-vivo
dc.subjectCaco-2
dc.subjectTransport
dc.subjectPermeability
dc.subjectEpirubicin
dc.subjectBehavior
dc.subjectCells
dc.titleThe intestinal permeation of didanosine from granules containing microspheres using the everted gut sac model
dc.typeArtículos de revistas


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