The influence of sex and ovarian hormones on temporomandibular joint nociception in rats

dc.creatorFischer, L
dc.creatorTorres-Chavez, KE
dc.creatorClemente-Napimoga, T
dc.creatorJorge, D
dc.creatorArsati, F
dc.creatorVeiga, MCFD
dc.creatorTambeli, CH
dc.date2008
dc.dateJUL
dc.date2014-11-14T12:16:17Z
dc.date2015-11-26T16:06:33Z
dc.date2014-11-14T12:16:17Z
dc.date2015-11-26T16:06:33Z
dc.date.accessioned2018-03-28T22:55:21Z
dc.date.available2018-03-28T22:55:21Z
dc.identifierJournal Of Pain. Churchill Livingstone, v. 9, n. 7, n. 630, n. 638, 2008.
dc.identifier1526-5900
dc.identifierWOS:000257640100008
dc.identifier10.1016/j.jpain.2008.02.006
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73503
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/73503
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73503
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265942
dc.descriptionThe aim of this study was to investigate the influence of sex and ovarian hormones on formalin- and glutamate-induced temporomandibular joint (TMJ) nociception in rats. The influence of sex and ovarian hormones on the nociceptive behavior induced by formalin or glutamate was virtually the same. The nociceptive behavior of males was similar to that of females in the proestrus phase of the estrous cycle but was significantly lower than that in the diestrus phase. Since the serum level of estradiol but not of progesterone was significantly higher in the proestrus than in the diestrus phase, these data suggest that females with lower endogenous serum level of estradiol have an exacerbation of TMJ nociception. The nociceptive behavior of ovariectomized rats was similar to that of diestrus females and significantly greater than that of proestrus females. Although the administration of estradiol or progesterone in ovariectomized females significantly reduced TMJ nociception, the combination of both hormones did not increase the antinociceptive effect induced by each of them. These findings suggest that estradiol and progesterone decrease TMJ nociception in an independent way. Perspective: We report that ovarian hormones have an antinociceptive effect on the TMJ formalin and glutamate nociceptive behavior models. Therefore, the greater prevalence and severity of TMJ pain in women of reproductive age may be a consequence of hormonal fluctuation during the reproductive cycle, in that during low endogenous estradiol serum level TMJ pain sensitivity is increased, enhancing the risk of females experiencing TMJ pain. (C) 2008 by the American Pain Society.
dc.description9
dc.description7
dc.description630
dc.description638
dc.languageen
dc.publisherChurchill Livingstone
dc.publisherEdinburgh
dc.publisherEscócia
dc.relationJournal Of Pain
dc.relationJ. Pain
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectformalin
dc.subjectglutamate
dc.subjectestrogen
dc.subjectprogesterone
dc.subjecttemporomandibular joint pain
dc.subjectsex differences
dc.subjectDorsal Raphe Nucleus
dc.subjectNeuropathic Pain
dc.subjectEstrous-cycle
dc.subjectBarbiturate Anesthesia
dc.subjectVentromedial Medulla
dc.subjectOvariectomized Rats
dc.subjectFormalin Test
dc.subjectFemale Rats
dc.subjectProgesterone
dc.subjectEstradiol
dc.titleThe influence of sex and ovarian hormones on temporomandibular joint nociception in rats
dc.typeArtículos de revistas


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