Subclinical hypothyroidism increases the risk for depression in the elderly

dc.creatorChueire, VB
dc.creatorRomaldini, JH
dc.creatorWard, LS
dc.date2007
dc.dateJAN-FEB
dc.date2014-11-14T10:39:29Z
dc.date2015-11-26T16:05:55Z
dc.date2014-11-14T10:39:29Z
dc.date2015-11-26T16:05:55Z
dc.date.accessioned2018-03-28T22:54:54Z
dc.date.available2018-03-28T22:54:54Z
dc.identifierArchives Of Gerontology And Geriatrics. Elsevier Ireland Ltd, v. 44, n. 1, n. 21, n. 28, 2007.
dc.identifier0167-4943
dc.identifierWOS:000242737500003
dc.identifier10.1016/j.archger.2006.02.001
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74638
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/74638
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74638
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265826
dc.descriptionin order to determine if subclinical hypothyroidism is a risk factor for depression in the elderly, a total of 323 individuals over 60 years old were interviewed using the Structured Clinical Interview for Diagnosis and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) for mood disturbances. Patients were divided into Group 1: 252 patients (184 females, 68 males; median age: 67 years, range: 60-89 years) with elevated serum thyrotropin (TSH) levels and Group 11: 71 patients (45 females, 26 males; median age: 67 years, range: 60-92 years) with diagnosis of depression. Serum TSH and free thyroxine (fT4) were measured by sensitive assays. Thyroid antibodies were determined by IRMA. Depression was observed in 24 (9.5%) Group I patients and was frequent in subclinical hypothyroidism patients (14/24 = 58.3%). On the other hand, elevated TSH levels were found in 22 (30.9%) Group 11 patients. Depression was observed more frequently among individuals with subclinical (74/149 = 49.7%) hypothyroidism than among individuals with overt hypothyroidism (21/125 = 16.8%) (p < 0.001). Indeed, subclinical hypothyroidism increased the risk for a patient to present depression more than four times (OR = 4.886; 95% confidence interval = 2.768-8.627). Our results demonstrate that subclinical hypothyroidism increases the risk for depression and emphasize the importance of thyroid screening tests in the elderly. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
dc.description44
dc.description1
dc.description21
dc.description28
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationArchives Of Gerontology And Geriatrics
dc.relationArch. Gerontol. Geriatr.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectTSH level
dc.subjectmood disorder
dc.subjectsubclinical hypothyroidism
dc.subjectL-thyroxine Treatment
dc.subjectThyroid-hormone
dc.subjectMood Disorders
dc.subjectDouble-blind
dc.subjectSerum Tsh
dc.subjectOld-age
dc.subjectAnxiety
dc.subjectAssociation
dc.subjectDysfunction
dc.subjectPrevalence
dc.titleSubclinical hypothyroidism increases the risk for depression in the elderly
dc.typeArtículos de revistas


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