Salivary gland tumors in children and adolescents: a clinicopathologic and immunohistochemical study of fifty-three cases

dc.creatorPerez, DED
dc.creatorPires, FR
dc.creatorAlves, FA
dc.creatorAlmeida, OP
dc.creatorKowalski, LP
dc.date2004
dc.dateJUL
dc.date2014-11-20T04:23:08Z
dc.date2015-11-26T16:05:33Z
dc.date2014-11-20T04:23:08Z
dc.date2015-11-26T16:05:33Z
dc.date.accessioned2018-03-28T22:54:32Z
dc.date.available2018-03-28T22:54:32Z
dc.identifierInternational Journal Of Pediatric Otorhinolaryngology. Elsevier Ireland Ltd, v. 68, n. 7, n. 895, n. 902, 2004.
dc.identifier0165-5876
dc.identifier1872-8464
dc.identifierWOS:000222141500005
dc.identifier10.1016/j.ijporl.2004.02.004
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71628
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71628
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71628
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265735
dc.descriptionObjective: Salivary gland tumors in children and adolescents are rare. Most papers are case reports or short series of cases. The aim of this study was to analyze clinicopathological and immunohistochemical data from a large series of salivary gland tumors affecting youngsters from a single institution. Methods: From 1953 to 1997, 53 patients 18 years old or less with epithelial salivary gland tumors from the Hospital do Cancer A.C. Camargo were studied. Clinical. and treatment data were obtained from the medical records and histological features were reviewed. Paraffin-embedded tissues were immunohistochemically analyzed for p53, PCNA, Ki-67, bcl-2, c-erbB-2, and CEA. Results: Twenty-seven tumors (51%) were benign and 26 (49%) malignant. Pleomorphic adenoma (PA) was the most common tumor type (49%), followed by mucoepidermoid carcinoma (MEC, 39.6%). The tumors were more common in female and 50.9% of the cases affected the parotid, followed by 26.4% of intraoral involvement. Immunohistochemical analysis did not show correlation with prognosis of the tumors. Twenty (74%) of the 27 patients with benign tumors were alive without evidence of disease after a mean of 16.5 years of follow up; 6 were lost of follow up and 1 died by causes not related to the disease. Nineteen (73%) of the 26 patients with malignant tumors did not show tumoral recurrence after a mean follow up of 14.3 years, and 3 (11.5%) patients died of the disease. Conclusions: In 53 cases of epithelial salivary gland tumors in youngsters, half were malignant, with favorable prognosis. On this series, immunohistochemical expression of p53, PCNA, Ki-67, c-erbB-2, bcl-2, and CEA, were not correlated with prognosis. (C) 2004 Elsevier Ireland Ltd. ALL rights reserved.
dc.description68
dc.description7
dc.description895
dc.description902
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationInternational Journal Of Pediatric Otorhinolaryngology
dc.relationInt. J. Pediatr. Otorhinolaryngol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectadolescents
dc.subjectchildren
dc.subjectimmunchistochemistry
dc.subjectsalivary gland tumors
dc.subjectMucoepidermoid Carcinoma
dc.subjectParotid-gland
dc.subjectExpression
dc.subjectNeoplasms
dc.subjectP53
dc.subjectApoptosis
dc.subjectC-erbb-2
dc.subjectProliferation
dc.subjectMarkers
dc.subjectBenign
dc.titleSalivary gland tumors in children and adolescents: a clinicopathologic and immunohistochemical study of fifty-three cases
dc.typeArtículos de revistas


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