MRI shows dorsal lesions and spinal cord atrophy in chronic sensory neuronopathies

dc.creatorFranca, MC
dc.creatorAbreu, AD
dc.creatorZanardi, VA
dc.creatorFaria, AV
dc.creatorLopes-Cendes, I
dc.creatorNucci, A
dc.creatorCendes, F
dc.date2008
dc.dateAPR
dc.date2014-11-14T06:07:16Z
dc.date2015-11-26T16:04:46Z
dc.date2014-11-14T06:07:16Z
dc.date2015-11-26T16:04:46Z
dc.date.accessioned2018-03-28T22:53:54Z
dc.date.available2018-03-28T22:53:54Z
dc.identifierJournal Of Neuroimaging. Blackwell Publishing, v. 18, n. 2, n. 168, n. 172, 2008.
dc.identifier1051-2284
dc.identifierWOS:000254502200009
dc.identifier10.1111/j.1552-6569.2007.00193.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/82113
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/82113
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/82113
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265570
dc.descriptionBACKGROUND AND PURPOSE Sensory neuronopathies (SN) represent a specific subgroup of peripheral nervous system diseases, characterized by degeneration of dorsal root ganglia (DRG) and its projections. We tried to estimate the frequency and extent of spinal cord MRI abnormalities in a group of patients with SN and correlate these with clinical and neurophysiological features. METHODS We performed spinal cord MRI scans in 16 chronic SN patients. Images were analyzed for the presence of posterior hyperintense lesions on T2WI and cord areas at C3 level were obtained using a previously validated method. A group of 14 healthy controls with similar age and gender distribution was used for comparison. ANOVA was employed for statistical analysis. RESULTS Posterior T2WI lesions were found in 13 out of 16 patients. Cord areas were significantly smaller in SN patients than controls (84.3 x 97.2 mm(2), P < .05). Atrophy correlated with severity of sensory ataxia and neurophysiologic abnormalities but not with duration of disease. CONCLUSIONS These findings support volumetric spinal cord MRI as a useful tool in the assessment of chronic SN.
dc.description18
dc.description2
dc.description168
dc.description172
dc.languageen
dc.publisherBlackwell Publishing
dc.publisherOxford
dc.publisherInglaterra
dc.relationJournal Of Neuroimaging
dc.relationJ. Neuroimaging
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectsensory neuronopathy
dc.subjectmagnetic resonance imaging
dc.subjectspinal cord
dc.subjectHereditary Spastic Paraplegia
dc.subjectResonance-imaging Findings
dc.subjectMultiple-sclerosis
dc.subjectGanglionopathies
dc.subjectBrain
dc.titleMRI shows dorsal lesions and spinal cord atrophy in chronic sensory neuronopathies
dc.typeArtículos de revistas


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