Hypertension increases retinal inflammation in experimental diabetes: A possible mechanism for aggravation of diabetic retinopathy by hypertension

dc.creatorSilva, KC
dc.creatorPinto, CC
dc.creatorBiswas, SK
dc.creatorde Faria, JBL
dc.creatorde Faria, JML
dc.date2007
dc.date2014-11-14T05:43:07Z
dc.date2015-11-26T16:04:44Z
dc.date2014-11-14T05:43:07Z
dc.date2015-11-26T16:04:44Z
dc.date.accessioned2018-03-28T22:53:51Z
dc.date.available2018-03-28T22:53:51Z
dc.identifierCurrent Eye Research. Taylor & Francis Inc, v. 32, n. 6, n. 533, n. 541, 2007.
dc.identifier0271-3683
dc.identifierWOS:000247877000006
dc.identifier10.1080/02713680701435391
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69068
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69068
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69068
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265560
dc.descriptionInflammation is pivotal to the pathogenesis of diabetic retinopathy (DR). Hypertension is the main secondary risk factor associated with DR. The mechanisms by which hypertension increases the risk for DR are poorly understood. The aim of the current study was to investigate the contribution of genetic hypertension to early retinal inflammation in experimental diabetes. Diabetes was induced in 4-week-old (developing hypertension) and 12-week-old (fully hypertensive) spontaneously hypertensive rats (SHR) and age-matched control normotensive Wistar Kyoto (WKY) rats by administration of streptozotocin (50 mg/kg, i.v); after 20 days the rats were sacrificed and the retinas were collected. ED1 positive cells, ICAM-1 and VEGF levels were significantly higher in diabetic SHR in both prehypertensive and hypertensive ages (p < 0.005). NF-kappa B p65 levels were higher in prehypertensive SHR and in hypertensive diabetic SHR (p < 0.05). Induction of diabetes in normotensive WKY rats did not show any alteration in retinal expression of inflammatory parameters. Therefore, we conclude that the developing hypertension and also the fully developed hypertension lead to earlier development of inflammation in diabetic retina. Aggravation of the inflammatory process may be involved in the mechanism by which essential hypertension exacerbates retinopathy in the presence of diabetes.
dc.description32
dc.description6
dc.description533
dc.description541
dc.languageen
dc.publisherTaylor & Francis Inc
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationCurrent Eye Research
dc.relationCurr. Eye Res.
dc.rightsfechado
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.sourceWeb of Science
dc.subjectdiabetic retinopathy
dc.subjecthypertension
dc.subjectinflammation
dc.subjectmicroglia
dc.subjectSHR
dc.subjectAdhesion Molecule Expression
dc.subjectCentral-nervous-system
dc.subjectNecrosis-factor-alpha
dc.subjectNitric-oxide
dc.subjectAtherosclerosis Risk
dc.subjectAngiotensin-ii
dc.subjectBlood-pressure
dc.subjectGlial-cells
dc.subjectRat-brain
dc.subjectMicroglia
dc.titleHypertension increases retinal inflammation in experimental diabetes: A possible mechanism for aggravation of diabetic retinopathy by hypertension
dc.typeArtículos de revistas


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