Heart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscle

dc.creatorCarvalho, RF
dc.creatorDariolli, R
dc.creatorJustulin, LA
dc.creatorSugizaki, MM
dc.creatorOkoshi, MP
dc.creatorCicogna, AC
dc.creatorFelisbino, SL
dc.creatorDal Pai-Silva, M
dc.date2006
dc.dateDEC
dc.date2014-11-14T03:29:01Z
dc.date2015-11-26T16:04:17Z
dc.date2014-11-14T03:29:01Z
dc.date2015-11-26T16:04:17Z
dc.date.accessioned2018-03-28T22:53:22Z
dc.date.available2018-03-28T22:53:22Z
dc.identifierInternational Journal Of Experimental Pathology. Blackwell Publishing, v. 87, n. 6, n. 437, n. 443, 2006.
dc.identifier0959-9673
dc.identifierWOS:000242221900004
dc.identifier10.1111/j.1365-2613.2006.00497.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68636
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/68636
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68636
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265443
dc.descriptionHeart failure is associated with a skeletal muscle myopathy with cellular and extracellular alterations. The hypothesis of this investigation is that extracellular changes may be associated with enhanced mRNA expression and activity of matrix metalloproteinases (MMP). We examined MMP mRNA expression and MMP activity in Soleus (SOL), extensor digitorum longus (EDL), and diaphragm (DIA) muscles of young Wistar rat with monocrotaline-induced heart failure. Rats injected with saline served as age-matched controls. MMP2 and MMP9 mRNA contents were determined by RT-PCR and MMP activity by electrophoresis in gelatin-containing polyacrylamide gels in the presence of SDS under non-reducing conditions. Heart failure increased MMP9 mRNA expression and activity in SOL, EDL and DIA and MMP2 mRNA expression in DIA. These results suggest that MMP changes may contribute to the skeletal muscle myopathy during heart failure.
dc.description87
dc.description6
dc.description437
dc.description443
dc.languageen
dc.publisherBlackwell Publishing
dc.publisherOxford
dc.publisherInglaterra
dc.relationInternational Journal Of Experimental Pathology
dc.relationInt. J. Exp. Pathol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectextracellular matrix
dc.subjectheart failure
dc.subjectmetalloproteinases
dc.subjectskeletal muscle
dc.subjectWistar rats
dc.subjectTumor-necrosis-factor
dc.subjectNf-kappa-b
dc.subjectBiochemical-changes
dc.subjectCardiac Cachexia
dc.subjectHypertrophy
dc.subjectInhibitor
dc.subjectAbnormalities
dc.subjectApoptosis
dc.subjectAtrophy
dc.subjectCells
dc.titleHeart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscle
dc.typeArtículos de revistas


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