Oxidative stress biomarkers and heart function in bullfrog tadpoles exposed to Roundup Original (R)

dc.creatorCosta, MJ
dc.creatorMonteiro, DA
dc.creatorOliveira-Neto, AL
dc.creatorRantin, FT
dc.creatorKalinin, AL
dc.date2008
dc.dateAPR
dc.date2014-11-14T02:22:18Z
dc.date2015-11-26T16:03:54Z
dc.date2014-11-14T02:22:18Z
dc.date2015-11-26T16:03:54Z
dc.date.accessioned2018-03-28T22:53:06Z
dc.date.available2018-03-28T22:53:06Z
dc.identifierEcotoxicology. Springer, v. 17, n. 3, n. 153, n. 163, 2008.
dc.identifier0963-9292
dc.identifierWOS:000252798400002
dc.identifier10.1007/s10646-007-0178-5
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81585
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/81585
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81585
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265374
dc.descriptionOxidative stress biomarkers, in vivo heart rate (f(H)), and contraction dynamics of ventricle strips of bullfrog (Lithobates catesbeiana) tadpoles were evaluated after 48 h of exposure to a sub-lethal concentration (1 ppm) of the herbicide Roundup Original (R) (glyphosate 41%). The activities of the antioxidant enzymes superoxide dismutase and catalase were increased in the liver and decreased in muscle, while oxidative damage to lipids increased above control values in both tissues, showing that the generation of reactive oxygen species and oxidative stress are involved in the toxicity induced by Roundup (R). Additionally, tadpoles' hyperactivity was associated with tachycardia in vivo, probably due to a stress-induced adrenergic stimulation. Ventricle strips of Roundup (R)-exposed tadpoles (R-group) presented a faster relaxation and also a higher cardiac pumping capacity at the in vivo contraction frequency, indicating that bullfrog tadpoles were able to perform cardiac mechanistic adjustments to face Roundup (R)-exposure. However, the lower maximal in vitro contraction frequency of the R-group could limit its in vivo cardiac performance, when the adrenergic-stimulation is present. The association between the high energetic cost to counteract the harmful effects of this herbicide and the induction of oxidative stress suggest that low and realistic concentrations of Roundup (R) can have an impact on tadpoles' performance and success, jeopardizing their survival and/or population establishment.
dc.description17
dc.description3
dc.description153
dc.description163
dc.languageen
dc.publisherSpringer
dc.publisherDordrecht
dc.publisherHolanda
dc.relationEcotoxicology
dc.relationEcotoxicology
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectRoundup (R)
dc.subjectoxidative stress biomarkers
dc.subjectcardiac contractility
dc.subjectbullfrog tadpoles
dc.subjectLithobates catesbeiana
dc.subjectLarval Xenopus-laevis
dc.subjectToad Bufo-marinus
dc.subjectRana-catesbeiana
dc.subjectAnuran Amphibians
dc.subjectNitric-oxide
dc.subjectAquatic Communities
dc.subjectOxygen-consumption
dc.subjectLipid-peroxidation
dc.subjectCyprinus-carpio
dc.subjectComet Assay
dc.titleOxidative stress biomarkers and heart function in bullfrog tadpoles exposed to Roundup Original (R)
dc.typeArtículos de revistas


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