Volumetric Capnography for the Evaluation of Pulmonary Disease in Adult Patients with Cystic Fibrosis and Noncystic Fibrosis Bronchiectasis

dc.creatorVeronez, L
dc.creatorMoreira, MM
dc.creatorSoares, STP
dc.creatorPereira, MC
dc.creatorRibeiro, MAGO
dc.creatorRibeiro, JD
dc.creatorTerzi, RGG
dc.creatorMartins, LC
dc.creatorPaschoal, IA
dc.date2010
dc.dateJUN
dc.date2014-11-14T00:49:05Z
dc.date2015-11-26T16:03:36Z
dc.date2014-11-14T00:49:05Z
dc.date2015-11-26T16:03:36Z
dc.date.accessioned2018-03-28T22:52:50Z
dc.date.available2018-03-28T22:52:50Z
dc.identifierLung. Springer, v. 188, n. 3, n. 263, n. 268, 2010.
dc.identifier0341-2040
dc.identifierWOS:000276910400012
dc.identifier10.1007/s00408-009-9213-z
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76231
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/76231
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76231
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265305
dc.descriptionThis study was designed to use volumetric capnography to evaluate the breathing pattern and ventilation inhomogeneities in patients with chronic sputum production and bronchiectasis and to correlate the phase 3 slope of the capnographic curve to spirometric measurements. Twenty-four patients with cystic fibrosis (CF) and 21 patients with noncystic fibrosis idiopathic bronchiectasis (BC) were serially enrolled. The diagnosis of cystic fibrosis was based on the finding of at least two abnormal sweat chloride concentrations (iontophoresis sweat test). The diagnosis of bronchiectasis was made when the patient had a complaint of chronic sputum production and compatible findings at high-resolution computed tomography (HRCT) scan of the thorax. Spirometric tests and volumetric capnography were performed. The 114 subjects of the control group for capnographic variables were nonsmoker volunteers, who had no respiratory symptoms whatsoever and no past or present history of lung disease. Compared with controls, patients in CF group had lower SpO(2) (P < 0.0001), higher respiratory rates (RR) (P < 0.0001), smaller expiratory volumes normalized for weight (V(E)/kg) (P < 0.028), smaller expiratory times (Te) (P < 0.0001), and greater phase 3 Slopes normalized for tidal volume (P3Slp/V(E)) (P < 0.0001). Compared with controls, patients in the BC group had lower SpO(2) (P < 0.0001), higher RR (P < 0.004), smaller V(E)/kg (P < 0.04), smaller Te (P < 0.007), greater P3Slp/V(E) (P < 0.0001), and smaller VCO(2) (P < 0.0002). The pooled data from the two patient groups compared with controls showed that the patients had lower SpO(2) (P < 0.0001), higher RR (P < 0.0001), smaller V(E)/kg (P < 0.05), smaller Te (P < 0.0001), greater P3Slp/V(E) (P < 0.0001), and smaller VCO(2) (P < 0.0003). All of the capnographic and spirometric variables evaluated showed no significant differences between CF and BC patients. Spirometric data in this study reveals that the patients had obstructive defects with concomitant low vital capacities and both groups had very similar abnormalities. The capnographic variables in the patient group suggest a restrictive respiratory pattern (greater respiratory rates, smaller expiratory times and expiratory volumes, normal peak expiratory flows). Both groups of patients showed increased phase III slopes compared with controls, which probably indicates the presence of diffuse disease of small airways in both conditions leading to inhomogeneities of ventilation.
dc.description188
dc.description3
dc.description263
dc.description268
dc.languageen
dc.publisherSpringer
dc.publisherNew York
dc.publisherEUA
dc.relationLung
dc.relationLung
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectRespiratory rate
dc.subjectVolume of CO(2) expired
dc.subjectExpiratory volume
dc.subjectPeak expiratory flow
dc.subjectVolume of CO(2) expired per breath
dc.subjectPhase 3 slope
dc.subjectPhase 3 slope/V(E)
dc.subjectPulse oximeter saturation
dc.subjectExpiratory time
dc.subjectVolumetric capnography
dc.subjectBronchiectasis
dc.subjectCystic fibrosis
dc.subjectAlveolar Plateau
dc.subjectFunction Tests
dc.subjectBronchiolitis
dc.subjectVentilation
dc.subjectObstruction
dc.subjectChildren
dc.subjectAirways
dc.titleVolumetric Capnography for the Evaluation of Pulmonary Disease in Adult Patients with Cystic Fibrosis and Noncystic Fibrosis Bronchiectasis
dc.typeArtículos de revistas


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