Histomorphology and ultrastructure of pancreatic islet tissue during in vivo maturation of rat pancreas

dc.creatorCarvalho, CPDF
dc.creatorMartins, JCR
dc.creatorDa Cunha, DA
dc.creatorBoschero, AC
dc.creatorCollares-Buzato, CB
dc.date2006
dc.dateMAY
dc.date2014-11-14T00:42:18Z
dc.date2015-11-26T16:03:30Z
dc.date2014-11-14T00:42:18Z
dc.date2015-11-26T16:03:30Z
dc.date.accessioned2018-03-28T22:52:44Z
dc.date.available2018-03-28T22:52:44Z
dc.identifierAnnals Of Anatomy-anatomischer Anzeiger. Elsevier Gmbh, Urban & Fischer Verlag, v. 188, n. 3, n. 221, n. 234, 2006.
dc.identifier0940-9602
dc.identifierWOS:000237606000005
dc.identifier10.1016/j.annat.2005.10.009
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69872
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69872
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69872
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265281
dc.descriptionIn this study, we have investigated the structural and ultrastructural features of pancreatic islet tissue during rat postnatal development. For this purpose, we used neonatal (1-2 days old), young (21 days old) and adult (3-4 months old) rats. From a functional point of view, neonatal islet tissue displayed a relatively poor insulin secretary response to glucose stimulation in comparison with the adult ones. Histological analysis showed that neonatal islet cells display a less organized morphology in comparison with the young and adult ones, characterized by a less defined form and the presence of ductal structures within or nearby the islet. Regarding the islet cytoarchitecture, no differences were observed among at[ animal groups studied. B-cells were always typically detected within the islet core while A-cells occupied the islet periphery area. No marked differences were found during postnatal animal development regarding the uttrastructural aspect of the endocrine cells and their secretary granules. Nevertheless, quantitative analysis showed a lower B-cell/non-B-cell ratio, a higher association with ducts and an increased immunoreaction for proliferating cell nuclear antigen (PCNA) in neonatal islets as compared to young and adults. In conclusion, the acquisition of an adult pattern of insulin secretion may require an appropriate histoarchitecture and B-cell/non-B-cell proportion that may affect crucial regulatory events such as the paracrine and/or the cell-cell interaction or communication within the islet. (c) 2005 Elsevier GmbH. All rights reserved.
dc.description188
dc.description3
dc.description221
dc.description234
dc.languageen
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.publisherJena
dc.publisherAlemanha
dc.relationAnnals Of Anatomy-anatomischer Anzeiger
dc.relationAnn. Anat.-Anat. Anz.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectdifferentiation
dc.subjectendocrine pancreas
dc.subjectinsulin secretion
dc.subjectpostnatal
dc.subjectdevelopment
dc.subjectmorphology
dc.subjectProgressive Histopathological Changes
dc.subjectCell-type Segregation
dc.subjectDiabetic Fatty Rats
dc.subjectMolecule N-cam
dc.subjectEndocrine Pancreas
dc.subjectInsulin-secretion
dc.subjectTransgenic Mice
dc.subjectBeta-cells
dc.subjectAdult-rat
dc.subjectB-cells
dc.titleHistomorphology and ultrastructure of pancreatic islet tissue during in vivo maturation of rat pancreas
dc.typeArtículos de revistas


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