Voxel-based morphometry of brain SPECT can detect the presence of active central nervous system involvement in systemic lupus erythematosus

dc.creatorAppenzeller, S
dc.creatorAmorim, BJ
dc.creatorRamos, CD
dc.creatorRio, PA
dc.creatorEtchebehere, ECSD
dc.creatorCamargo, EE
dc.creatorCendes, F
dc.creatorCostallat, LTL
dc.date2007
dc.dateMAR
dc.date2014-11-14T00:14:18Z
dc.date2015-11-26T16:03:24Z
dc.date2014-11-14T00:14:18Z
dc.date2015-11-26T16:03:24Z
dc.date.accessioned2018-03-28T22:52:39Z
dc.date.available2018-03-28T22:52:39Z
dc.identifierRheumatology. Oxford Univ Press, v. 46, n. 3, n. 467, n. 472, 2007.
dc.identifier1462-0324
dc.identifierWOS:000244427500019
dc.identifier10.1093/rheumatology/kel255
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76251
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/76251
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76251
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265258
dc.descriptionObjective. To determine the value of voxel-based morphometry (VBM) of brain SPECT (single-photon emission computed tomography) images (BSI) in discriminating active central nervous system (CNS) manifestations in systemic lupus erythematosus (SLE) patients. Patients and Methods. Forty SLE patients (mean age 33 yrs) and 33 normal volunteers were submitted to BSI. SLE patients were screened for the presence of CNS involvement following the American College of Rheumatology (ACR) case definition. Patients with CNS infections, uraemia, diabetes and previous ischaemic or haemorrhagic stroke were excluded. Magnetic resonance imaging (MRI) scans were obtained in a 2T scanner (Elscint Prestige) with T1- and T2-weighted images. BSI were performed after injection of 1110 MBq (30 mCi) of Tc-99m-ECD (ethyl-cysteinate-dimer). BSI were analysed using the statistical parametric mapping. After normalization, segmentation and smoothing the groups of SLE patients with active and inactive CNS manifestations and healthy volunteers were compared using VBM. Post-processed images were compared voxel-by-voxel using t-test in order to determine differences of intensity between groups. This analysis included grand mean scaling, proportional threshold masking (set to 0.4) and implicit masking. A P-value of 0.001 and cluster size of 32 were taken into consideration. Results. VBM analyses of BSI did not show any differences between SLE patients with inactive CNS involvement and normal controls. However, the group of SLE patients with active CNS involvement had a global hypoperfusion, more intense in the frontal, dorsolateral and medial temporal lobe when compared with SLE patients without CNS involvement (P = 0.001) and healthy volunteers (P = 0.001). Conclusion. VBM of BSI is a useful and objective method for detecting perfusion abnormalities in SLE patients, which is indicative of active CNS involvement. However, it is not helpful in differentiating the clinical sub-types of CNS involvement according to the ACR classification.
dc.description46
dc.description3
dc.description467
dc.description472
dc.languageen
dc.publisherOxford Univ Press
dc.publisherOxford
dc.publisherInglaterra
dc.relationRheumatology
dc.relationRHEUMATOLOGY
dc.rightsfechado
dc.rightshttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.sourceWeb of Science
dc.subjectSPECT
dc.subjectVBM
dc.subjectSLE
dc.subjectCerebral-blood-flow
dc.subjectEmission Computed-tomography
dc.subjectMagnetic-resonance Spectroscopy
dc.subjectNeuropsychiatric Lupus
dc.subjectClinical Manifestations
dc.subjectImage Registration
dc.subjectPartial Seizures
dc.subjectMri Findings
dc.subjectValidation
dc.subjectSle
dc.titleVoxel-based morphometry of brain SPECT can detect the presence of active central nervous system involvement in systemic lupus erythematosus
dc.typeArtículos de revistas


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