The role of heart rate in the modulation of the decreased cardiac output induced by acute nitric oxide synthesis inhibition in anaesthetized dogs

dc.creatorFaro, R
dc.creatorTanus-Santos, JE
dc.creatorZappellini, A
dc.creatorAntunes, E
dc.creatorDe Nucci, G
dc.date1999
dc.dateOCT
dc.date2014-12-02T16:27:45Z
dc.date2015-11-26T16:02:58Z
dc.date2014-12-02T16:27:45Z
dc.date2015-11-26T16:02:58Z
dc.date.accessioned2018-03-28T22:52:22Z
dc.date.available2018-03-28T22:52:22Z
dc.identifierJournal Of Autonomic Pharmacology. Blackwell Science Ltd, v. 19, n. 5, n. 257, n. 262, 1999.
dc.identifier0144-1795
dc.identifierWOS:000085660800001
dc.identifier10.1046/j.1365-2680.1999.00141.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/72378
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/72378
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/72378
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265186
dc.description1 The role of the heart rate modulating the decrease in cardiac output induced by the nitric oxide synthesis inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME) was investigated in anaesthetized dogs. This was achieved in dogs in which a positive pacemaker (PM) cable was located at the right ventricle. 2 The haemodynamic events were evaluated: mean arterial blood pressure (MABP), systemic vascular resistance index (SVRI), stroke volume index (SVI), heart rate (HR) and cardiac index (CI). 3 The infusion of L-NAME (0.01-10 mg kg(-1)) in the animals with the PM off caused a dose-dependent rise in MABP and SVRI, accompanied by significant decreases of HR and SVI. A resulting decrease in CI was observed at all doses of L-NAME used. 4 In the animals with the PM on, HR was maintained stable. Under this condition, the increase in MABP and SVRI as well as the decrease in SVI induced by the L-NAME infusion did not significantly differ from the PM-off animals. However, the resulting decreased CI was markedly attenuated compared to PM-off animals but significant decreases in CI were still observed at higher doses of L-NAME. 5 The results suggest that HR plays an important role in the L-NAME-mediated decreased cardiac output but other factors might also be involved.
dc.description19
dc.description5
dc.description257
dc.description262
dc.languageen
dc.publisherBlackwell Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationJournal Of Autonomic Pharmacology
dc.relationJ. Auton. Pharmacol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectArginine Methyl-ester
dc.subjectLong Evans Rats
dc.subjectAnesthetized Dogs
dc.subjectCoronary Vasoconstriction
dc.subjectIn-vivo
dc.subjectResponses
dc.titleThe role of heart rate in the modulation of the decreased cardiac output induced by acute nitric oxide synthesis inhibition in anaesthetized dogs
dc.typeArtículos de revistas


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