Gene amplification is a mechanism of SW overexpression in breast cancer

dc.creatorReichenberger, KJ
dc.creatorColetta, RD
dc.creatorSchulte, AP
dc.creatorVarella-Garcia, M
dc.creatorFord, HL
dc.date2005
dc.dateAPR 1
dc.date2014-11-13T20:09:01Z
dc.date2015-11-26T16:02:09Z
dc.date2014-11-13T20:09:01Z
dc.date2015-11-26T16:02:09Z
dc.date.accessioned2018-03-28T22:51:36Z
dc.date.available2018-03-28T22:51:36Z
dc.identifierCancer Research. Amer Assoc Cancer Research, v. 65, n. 7, n. 2668, n. 2675, 2005.
dc.identifier0008-5472
dc.identifierWOS:000227972300026
dc.identifier10.1158/0008-5472.CAN-04-4286
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/67834
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/67834
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/67834
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1264997
dc.descriptionThe Six1 homeoprotein plays a critical role in expanding progenitor populations during normal development via its stimulation of proliferation and inhibition of apoptosis. Overexpression of Six1 is observed in several tumor types, suggesting that when expressed out of context, Six1 may contribute to tumorigenesis by reinstating properties normally conveyed on developing cells. Indeed, Six1 contributes to tumor cell proliferation both in breast cancer and in rhabdomyosarcomas, in which it is also implicated in metastasis. Whereas Six1 overexpression has been reported in several tumor types, the mechanism responsible for its overexpression has not previously been examined. Here we show that a change in gene dosage may contribute to Six1 mRNA overexpression. Significant Six1 gene amplification and overrepresentation occurs in numerous breast cancer cell lines as compared with normal mammary epithelial cells, and the changes in gene dosage correlate with increased Six1 mRNA levels. Of 214 human infiltrating ductal breast carcinomas examined for Six1 gene dosage, 4.7% show Six1 amplification/ overrepresentation, and tumors that exhibit an increase in Six1 gene dosage overexpress Six1 mRNA. These data implicate SUI gene amplification/overrepresentation as a mechanism of Six1 mRNA overexpression in human breast cancer.
dc.description65
dc.description7
dc.description2668
dc.description2675
dc.languageen
dc.publisherAmer Assoc Cancer Research
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationCancer Research
dc.relationCancer Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectComparative Genomic Hybridization
dc.subjectGrowth-factor Receptor
dc.subjectKinase-c-eta
dc.subjectCopy Number
dc.subjectTranscription Factors
dc.subjectCell-proliferation
dc.subjectProtein Expression
dc.subjectProstate-cancer
dc.subjectChromosome 14
dc.subjectPkc-eta
dc.titleGene amplification is a mechanism of SW overexpression in breast cancer
dc.typeArtículos de revistas


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