Anatomic evaluation of the orbitofrontal cortex in major depressive disorder

dc.creatorLacerda, ALT
dc.creatorKeshavan, MS
dc.creatorHardan, AY
dc.creatorYorbik, O
dc.creatorBrambilla, P
dc.creatorSassi, RB
dc.creatorNicoletti, M
dc.creatorMallinger, AG
dc.creatorFrank, E
dc.creatorKupfer, DJ
dc.creatorSoares, JC
dc.date2004
dc.dateFEB 15
dc.date2014-11-13T16:48:20Z
dc.date2015-11-26T16:01:27Z
dc.date2014-11-13T16:48:20Z
dc.date2015-11-26T16:01:27Z
dc.date.accessioned2018-03-28T22:51:05Z
dc.date.available2018-03-28T22:51:05Z
dc.identifierBiological Psychiatry. Elsevier Science Inc, v. 55, n. 4, n. 353, n. 358, 2004.
dc.identifier0006-3223
dc.identifierWOS:000188964700004
dc.identifier10.1016/j.biopsych.2003.08.021
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77396
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77396
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77396
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1264867
dc.descriptionBackground: The orbitofrontal cortex (OFC) plays a major role in neuropsychologic functioning including exteroceptive and interoceptive information coding, reward-guided behavior, impulse control, and mood regulation, This study examined the OFC and its subdivisions in patients with MDD and matched healthy control subjects. Methods. Magnetic resonance imaging (MRI) was performed on 31 unmedicated MDD and 34 control subjects matched for age, gender, and race. Gray matter volumes of the OFC and its lateral and medial subdivisions were measured blindly. Results: The MDD patients had smaller gray matter volumes in tight medial [two-way analysis of covariance F(1, 60) = 4.285; p = .043] and left lateral OFC [F (1, 60) = 4.252; p = .044]. Left lateral OFC volume correlated negatively with age in patients but not in control subjects. Male, but not female patients exhibited smaller left and right medial OFC volumes compared with healthy control subjects of the same gender. Conclusions: These findings suggest that patients with MDD have reduced OFC gray matter volumes. Although this reduction might be important in understanding the pathophysiology of MDD, its functional and psychopathologic consequences are as yet unclear. Future studies examining the relationship between specific symptomatic dimensions of MDD and OFC volumes could be especially informative.
dc.description55
dc.description4
dc.description353
dc.description358
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.publisherEUA
dc.relationBiological Psychiatry
dc.relationBiol. Psychiatry
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectneuroimaging
dc.subjectmagnetic resonance imaging
dc.subjectunipolar depression
dc.subjectprefrontal cortex
dc.subjectorbital frontal cortex
dc.subjectOFC
dc.subjectSubgenual Prefrontal Cortex
dc.subjectPositron-emission-tomography
dc.subjectCerebral-blood-flow
dc.subjectMood Disorders
dc.subjectGender Differences
dc.subjectFrontal-lobe
dc.subjectFunctional Neuroanatomy
dc.subjectUnipolar Depression
dc.subjectParkinsons-disease
dc.subjectOnset Depression
dc.titleAnatomic evaluation of the orbitofrontal cortex in major depressive disorder
dc.typeArtículos de revistas


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