Abnormal Production Of Transforming Growth Factor β And Interferon γ By Peripheral Blood Cells Of Patients With Multidrug-resistant Pulmonary Tuberculosis In Brazil

dc.creatorCastro A.Z.
dc.creatorDiaz-Bardalez B.M.
dc.creatorOliveira E.C.
dc.creatorGarcia R.C.
dc.creatorAfiune J.B.
dc.creatorPaschoal I.A.
dc.creatorSantos L.M.B.
dc.date2005
dc.date2015-06-26T14:07:03Z
dc.date2015-11-26T15:41:13Z
dc.date2015-06-26T14:07:03Z
dc.date2015-11-26T15:41:13Z
dc.date.accessioned2018-03-28T22:49:43Z
dc.date.available2018-03-28T22:49:43Z
dc.identifier
dc.identifierJournal Of Infection. , v. 51, n. 4, p. 318 - 324, 2005.
dc.identifier1634453
dc.identifier10.1016/j.jinf.2004.08.035
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-28044467549&partnerID=40&md5=f21ec6c9ab79d752092e1280e7ed20e1
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/93270
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/93270
dc.identifier2-s2.0-28044467549
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1264567
dc.descriptionObjective. The aim of the present study was to determine the immune response profile that differentiates patients with newly diagnosed (non-treated) pulmonary tuberculosis from multidrug-resistant (MDR) ones, as well as from healthy, tuberculin positive individuals. Methods. Lymphocytes proliferative response to non-specific mitogen (PHA) and PPD were evaluated by 3H thymidine incorporation and cytokines were quantified using an ELISA assay. Results. Patients with active disease showed a diminished proliferative response to PHA and PPD, while multidrug-resistant patients showed a diminished proliferative response to PHA, but a normal response to PPD. The cytokine production of newly diagnosed patients was characterized by a diminished production of IFNγ and normal production of transforming growth factor (TGFβ), while MDR patients revealed a normal production of IFNγ accompanied by an increase in TGFβ. Conclusions. The production of significant amounts of TGFβ in MDR patients leads to a poor immune response and may contribute to the resistance of tuberculosis patients to drugs. © 2005 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
dc.description51
dc.description4
dc.description318
dc.description324
dc.descriptionFlesch, I.E., Kaufmann, S.H., Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor (1990) Infect. Immun., 58 (8), pp. 2675-2677
dc.descriptionMosmann, T.R., Sad, S., The expanding universe of T-cell subsets: Th1, Th2 and more (1996) Immunol. Today, 17 (3), pp. 138-146
dc.descriptionBonecini-Almeida, M., Chitale, S., Boutsikakis, I., Geng, J., Doo, H., He, S., Ho, J.L., Induction of in vitro human macrophage anti-Mycobacterium tuberculosis activity: Requirement for IFN-gamma and primed lymphocytes (1998) J. Immunol., 160 (9), pp. 4490-4499
dc.descriptionCooper, A.M., Flynn, J.L., The protective immune response to Mycobacterium tuberculosis (1995) Curr. Opin. Immunol., 7 (1), pp. 512-516
dc.descriptionOrme, I.M., Roberts, A.D., Griffin, J.P., Abrams, J.S., Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection (1993) J. Immunol., 151 (1), pp. 518-525
dc.descriptionRojas, R.E., Balaji, K.N., Subramanian, A., Boom, W.H., Regulation of human CD4(+) αβ T cell receptor (+) and γδ TCR (+) T cell response to Mycobacterium tuberculosis by interleukin-10 and transforming growth factor beta (1999) Infect. Immun., 67 (12), pp. 6461-6472
dc.descriptionGong, J.H., Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA4 expression (1996) Infect. Immun., 64 (3), pp. 913-918
dc.descriptionDiaz-Bardales, B.M., Modulation of the severity of experimental autoimmune encephalomyelitis by γδ T lymphocytes activated by mycobacterial antigens (2001) Immunol. Invest., 30 (3), pp. 245-258
dc.descriptionMurray, P.J., Wang, L., Onufryk, C., Tepper, R.I., Young, R.A., T cell-derived IL10 antagonizes macrophage function in mycobacteria infection (1997) J. Immunol., 158 (1), pp. 315-321
dc.descriptionFrieden, T.R., The emergence of drug resistant tuberculosis in New York city (1993) N. Engl. J. Med., 328 (8), pp. 521-526
dc.descriptionSantos, L.M.B., Al-Sabbagh, A., Londono, A., Sobel, R.A., Weiner, H.L., Oral tolerance to myelin basic protein induces regulatory TGF β secreting T cell in Peyer's patches (1994) Cell Immunol., 157 (2), pp. 439-447
dc.descriptionFlynn, J.L., Chan, J., Immunology of tuberculosis (2001) Annu. Rev. Immunol., 19, pp. 93-129
dc.descriptionFenton, M.J., Induction of gamma-interferon production in human alveolar macrophages by Mycobacterium tuberculosis (1997) Infect. Immun., 65 (12), pp. 5149-5156
dc.descriptionFlynn, J.L., An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection (1993) J. Exp. Med., 178 (6), pp. 2249-2254
dc.descriptionCooper, A.M., Disseminated tuberculosis in IFN-γ gene-disrupted mice (1993) J. Exp. Med., 178 (6), pp. 2243-2247
dc.descriptionLyadova, I., An ex vivo study of T lymphocytes recovered from the lungs of I/St mice infected with and susceptible to Mycobacterium tuberculosis (1998) Infect. Immun., 66 (10), pp. 4981-4988
dc.descriptionFeng, C.G., Bean, A.G., Hooi, H., Briscoe, H.W., Britton, J., Increase in gamma interferon-secreting CD8(+), as well as CD4(+) T cells in lungs following aerosol infection with Mycobacterium tuberculosis (1999) Infect. Immun., 67 (7), pp. 3242-3247
dc.descriptionLalvani, A., Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis (1998) Proc. Natl. Acad. Sci. USA, 95 (1), pp. 270-275
dc.descriptionOrme, I.M., T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinects and recognition of a wide spectrum of protein antigens (1992) J. Immunol., 148 (1), pp. 189-196
dc.descriptionSerbina, N.V., Flynn, J.L., Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice (1999) Infect. Immun., 67 (8), pp. 3980-3988
dc.descriptionBarnes, P.F., Abrams, J.S., Lu, S., Sieling, P.A., Rea, T.H., Modlin, R.L., Patterns of cytokine production by mycobacterim reactive human T-cell clones (1993) Infect. Immun., 61 (1), pp. 197-203
dc.descriptionHirsch, C.S., Ellner, J.J., Blinkhorn, R., Toossi, Z., In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor beta (1997) Proc. Natl. Acad. Sci. USA, 94 (8), pp. 3926-3931
dc.descriptionToossi, Z., Gogate, P., Shiratsuchi, H., Young, T., Ellner, J.J., Enhanced production of TGF beta by blood monocytes from patients with active tuberculosis and presence of TGFβ in tuberculosis granulomatous lung lesions (1995) J. Immunol., 154 (1), pp. 465-473
dc.descriptionDahl, K.E., Shiratsuchi, H., Hamilton, B.D., Ellner, J.J., Toossi, Z., Selective induction of transforming growth factor beta in human monocytes by lipoarabinomannan oif Mycobacterium tuberculosis (1996) Infect. Immun., 64 (2), pp. 399-405
dc.descriptionGarcia, C.A., Oliveira, E.C., Sakurada, J.K., Santos, L.M.B., Protective immunity induced by a Trypanosoma cruzi soluble extract antigen in experimental Chagas disease. Role of IFN γ (2000) Immunol. Invest., 29 (1), pp. 1-12
dc.descriptionMiller, A., Al-Sabbagh, A., Santos, L.M.B., Prabhu Das, M., Weiner, H.L., Epitopes of myelin basic protein that trigger TGF β release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression (1993) J. Immunol., 151 (12), pp. 7307-7315
dc.descriptionTing, L.M., Kim, A.C., Cattamanchi, A., Ernest, J.D., Mycobacterium tuberculosis inhibit IFN gamma transcriptional responses without inhibiting activation of STAT1 (1999) J. Immunol., 163 (7), pp. 3898-3906
dc.descriptionDing, A., Nathan, C.F., Graycar, J., Derynck, R., Stuehr, D.J., Srimal, S., Macrophage deactivation factor and TGFβ 1,2,3, inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ (1990) J. Immunol., 145 (3), pp. 940-944
dc.languageen
dc.publisher
dc.relationJournal of Infection
dc.rightsfechado
dc.sourceScopus
dc.titleAbnormal Production Of Transforming Growth Factor β And Interferon γ By Peripheral Blood Cells Of Patients With Multidrug-resistant Pulmonary Tuberculosis In Brazil
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución