The postpartum period is thought to be a relatively high risk period in terms of experiencing a psychiatric disorder. This is particularly important for affective episodes, and for women with preexisting psychiatric illness. Between 5% and 20% of all women will experience a postpartum depression within the first six months, and 1% to 2% will experience a postpartum psychosis. The vulnerability for psychiatric illness during the period after delivery raises the possibility that psychotropic medications will be administered. Most psychotropic medications are excreted into breast milk, but there is great variability in the amount of drug received by the infant. Nevertheless, with the exception of case reports or small case series, there are few data on the safety of psychotropic medications during breastfeeding. The authors made an evaluation of currently published studies, and reviewed the existing data regarding the use of psychotropic agents in breastfeeding, in special its impact on infant's development. 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