Oxidative Stress And Susceptibility To Mitochondrial Permeability Transition Precedes The Onset Of Diabetes In Autoimmune Non-obese Diabetic Mice

dc.creatorMalaguti C.
dc.creatorLa Guardia P.G.
dc.creatorLeite A.C.R.
dc.creatorOliveira D.N.
dc.creatorDe Lima Zollner R.L.
dc.creatorCatharino R.R.
dc.creatorVercesi A.E.
dc.creatorOliveira H.C.F.
dc.date2014
dc.date2015-06-25T17:51:03Z
dc.date2015-11-26T15:39:56Z
dc.date2015-06-25T17:51:03Z
dc.date2015-11-26T15:39:56Z
dc.date.accessioned2018-03-28T22:48:24Z
dc.date.available2018-03-28T22:48:24Z
dc.identifier
dc.identifierFree Radical Research. Informa Healthcare, v. 48, n. 12, p. 1494 - 1504, 2014.
dc.identifier10715762
dc.identifier10.3109/10715762.2014.966706
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84908670728&partnerID=40&md5=65e50581ec4fe70704b78d21f77534a3
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85972
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85972
dc.identifier2-s2.0-84908670728
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1264251
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionBeta cell destruction in type 1 diabetes (TID) is associated with cellular oxidative stress and mitochondrial pathway of cell death. The aim of this study was to determine whether oxidative stress and mitochondrial dysfunction are present in T1D model (non-obese diabetic mouse, NOD) and if they are related to the stages of disease development. NOD mice were studied at three stages: non-diabetic, pre-diabetic, and diabetic and compared with age-matched Balb/c mice. Mitochondria respiration rates measured at phosphorylating and resting states in liver and soleus biopsies and in isolated liver mitochondria were similar in NOD and Balb/c mice at the three disease stages. However, NOD liver mitochondria were more susceptible to calcium-induced mitochondrial permeability transition as determined by cyclosporine-A-sensitive swelling and by decreased calcium retention capacity in all three stages of diabetes development. Mitochondria H2O2 production rate was higher in non-diabetic, but unaltered in pre-diabetic and diabetic NOD mice. The global cell reactive oxygen species (ROS), but not specific mitochondria ROS production, was significantly increased in NOD lymphomononuclear and stem cells in all disease stages. In addition, marked elevated rates of 2′,7′-dichlorodihydrofluorescein (H2DCF) oxidation were observed in pancreatic islets from non-diabetic NOD mice. Using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) and lipidomic approach, we identified oxidized lipid markers in NOD liver mitochondria for each disease stage, most of them being derivatives of diacylglycerols and phospholipids. These results suggest that the cellular oxidative stress precedes the establishment of diabetes and may be the cause of mitochondrial dysfunction that is involved in beta cell death.
dc.description48
dc.description12
dc.description1494
dc.description1504
dc.descriptionACRL; Association of College and Research Libraries; CAPES; Association of College and Research Libraries
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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dc.languageen
dc.publisherInforma Healthcare
dc.relationFree Radical Research
dc.rightsfechado
dc.sourceScopus
dc.titleOxidative Stress And Susceptibility To Mitochondrial Permeability Transition Precedes The Onset Of Diabetes In Autoimmune Non-obese Diabetic Mice
dc.typeArtículos de revistas


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