Artículos de revistas
Antimonials Employed In The Treatment Of Leishmaniaisis: The State Of The Art [antimoniais Empregados No Tratamento Da Leishmaniose: Estado Da Arte]
Registro en:
Quimica Nova. , v. 26, n. 4, p. 550 - 555, 2003.
1004042
2-s2.0-0742304906
Autor
Rath S.
Augusto Trivelin L.
Imbrunito T.R.
Tomazela D.M.
De Jesus M.N.
Calvo Marzal P.
De Andrade Jr. H.F.
Gustavo Tempone A.
Institución
Resumen
Antimony preparations are the drugs of choice for the treatment of leishmaniasis over 90 years, a disease that currently affects 12 million people worldwide. Its introduction was based on 19th century concepts of therapeutic effects of metal salts as arsenicals and other metals, most of them abandoned due to toxic effects or better drugs. In the last three decades, there was a great improvement in the knowledge of cell biology and immunology of those infections, but chemotherapy has not been improved in the same strength. The structure and mechanism of action of the two pentavalent antimonial drugs of choice, meglumine antimoniate and sodium stibogluconate, are not well known and the contamination of those pharmaceutical by toxic contaminants have been verified. 26 4 550 555 Goldman, L., (1983) Arch. Dermatol., 119, p. 540 http://www.dbbm.fiocruz.br/tropical/leishman/indice.htmlHoare, C.A., (1938) Trans. R. Soc. Trop. Med. Hyg., 32, p. 67 http://www.sucen.sp.gov.br/doencas/index.htmBerman, J.D., (1988) Rev. Infect. Dis., 10, p. 560 http://www.funasa.gov.br/pub/GVE/GVE0517A.htmGrimaldi, G., Tesh, A.B., McMahon, P.D., (1989) Am. J. Trop. Med. Hyg., 41, p. 689 http://www.who.int/emc/diseases/leish/leisgeol.htmlZorzetto, R., (2001) Pesquisa FAPESP, 68, p. 53 http://www.cve.saude.sp.gov.br/htm/leishvis.htmhttp://www.cve.saude.sp.gov.br/htm/inf_lva2000.htmVianna, G.O., (1912) Anais do 7° Congresso Brasileiro de Medicina e Cirurgia, 4, p. 426 Di Christina, G., Caronia, G., (1915) Bull. Soc. Pathol. Exot., 8, p. 63 Marsden, P.D., (1985) Rev. Soc. Bras. Med. Trop., 18, p. 187 Moore, E., O'Flaherty, D., Heuvelmans, H., Seaman, J., Veeken, H., Wit, S., Davidson, R.N., (2001) Bulletin of the World Health Organization, 79, p. 388 Limongi, J.P., (1973) Farmacodinâmica, , Corbett, C. E., ed. Livraria Editera Artes Médicas: São Paulo, cap. 61 Goldsmith, R.S., (1998) Farmacologia Básica e Clínica, , Katzung, B. G., ed. Guanabara Koogan S.A.: Rio de Janeiro, cap. 54 Balaña-Fouce, R., Reguera, R.M., Cubría, C., Ordóñez, D., (1998) Gen. Pharmacol., 30, p. 435 Sereno, D., Lemesre, J.L., (1997) Antimicrob. Agents Chemother., 41, p. 972 Berman, J.D., Wyler, D.J., (1980) J. Inf. Diseases, 142, p. 83 Roberts, W.L., McMurray, W.J., Rainey, P.M., (1998) Antimicrob. Agents Chemother., 42, p. 1076 Dórea, J.G., Costa, J.M.L., Holzbecher, J., Ryan, D.E., Marsden, P.D., (1987) Clin. Chem., 33, p. 2081 Demicheli, C., Figueiredo, T.L., Carvalho, S., Sinesterra, R.D., Lopes, J.C.D., Frezard, F., (1999) BioMetals, 12, p. 63 Bangs, J.D., Ransom, D.A., Nimick, M., Christie, G.H., (2001) Mol. Biochem. Parasitol., 114, p. 111 Miekeley, N., Mortari, S.R., Schubach, A.O., (2002) Anal. Bioanal. Chem., 372, p. 495 Doua, F., Miezan, T.W., Singaro, J.R.S., Yapo, F.B., Baltz, T., (1996) Am. J. Trop. Med. Hyg., 55, p. 586 Yardley, V., Croft, S.L., (2000) Int. J. Antimicrob. Agents, 13, p. 243 Rang, H.P., Dale, M.M., (1991) Pharmacology 2nd Ed., , Churchill Livingstone: UK Martinez, S., Marr, J.J., (1992) New Engl. J. Med., 326, p. 741 Fischer, C., Voss, A., Engel, J., (2001) Medical Microbiol. Immunolog., 190, p. 85 http://www-cie.iarc.fr/htdocs/monographs/vol47/47-11.htmGerhardsson, L., Brune, D., Nordberg, G.F., Wester, P.O., (1982) Scand. J. Work Environ. Health, 8, p. 201 Jones, R.D., (1994) Occup. Environ. Med., 51, p. 772 Groth, D.H., Stettler, L.E., Burg, J.R., Busey, W.M., Grant, G.C., Wong, L., (1986) J. Toxicol. Environ. Health, 18, p. 607 Gebel, T., (1997) Chem.-Biol. Interact., 107, p. 131 Felicetti, S.A., Thomas, R.G., McClellan, R.O., (1974) Am. Ind. Hyg. Assoc. J., 35, p. 292 Chulay, J.D., Fleckenstein, L., Smith, D.H., (1988) Trans. R. Soc. Trop. Med. Hyg., 82, p. 69 Rees, P.H., Kesting, M.I., Kager, P.A., Hockmeyer, W.T., (1980) Lancet, 2, p. 226 Pamplin, C.L., Desjadins, R., Chulay, J., Tramont, E., Henricks, L., Canfield, C., (1981) Clin. Pharm. Ther., 29, p. 270 Krachler, M., Emons, H., (2001) J. Anal. At. Spectrom., 16, p. 20 Bloomfield, M.S., Dow, D.A., Prebble, K.A., (1992) J. Pharm. Biomed. Anal., 10, p. 779 Franco, A., Barbosa, A.C., Rath, S., Dórea, J.G., (1995) Am. J. Trop. Med. Hyg., 52, p. 435 Rath, S., Jardim, W.F., Dórea, J.G., (1997) Fresenius' J. Anal. Chem., 358, p. 548 http://www.ufsm.br/farmacopeia/.html