The incorporation of chemical substances in environmental matrices, notably medicines and some endocrine disruptors, has been a factor of increasing concern by scientific community. These compounds, that have been called "emerging contaminants", are widely used by the modern society, and are characterized by their environmental impacts, even in low concentrations, since they interfere with the metabolism of various organisms, and result in disturbs of its population equilibrium. In this context, the medication discharge in its different forms, and the demand for strategies of management of these wastes, takes an important role. These strategies, to be worth need to consider the participation of professionals evolved at all the phases of the life cycle of medicines. This work presents a critical overview, based on a technical literature review and regulations analysis, about the effects of waste medicines on environment, especially on water bodies. ©Sociedade Brasileira de Toxicologia.221-218McClellan, K., Halden, R.U., Pharmaceuticals and personal care products in archived U.S. Biosolids from the 2001 EPA national sewage sludge survey (2010) Water Res, 44, pp. 658-668Fent, K., Weston, A.A., Caminada, D., Ecotoxicology of human pharmaceuticals (2006) Aquatic Toxicology, 76 (2), pp. 122-159. , DOI 10.1016/j.aquatox.2005.09.009, PII S0166445X05003267Länge, R., Hutchinson, T.H., Croudace, C.P., Siegmund, F., Effects of the synthectic strogen 17 alpha-ethinylestradiol on the life cycle of the fathead minnow (2001) Environ Toxicol Chem, 20, pp. 1216-1224Schwartz, T., Kohnen, W., Jansen, B., Detection of antibiotic-resistant bacteria and their resistence genes in wastewater, surface water and drinking water biofilms (2002) Micro Ecol, 1470, pp. 1-11Petersen, A., Andersen, J.S., Kaewmak, T., Somsiri, T., Dalsgaard, A., Impact of integrated fish farming on antimicrobial resistance in a pond environment (2002) Applied and Environmental Microbiology, 68 (12), pp. 6036-6042. , DOI 10.1128/AEM.68.12.6036-6042.2002Jones, O.A.H., Voulvoulis, N., Lester, J.N., Potential ecological and human health risks associated with the presence of pharmaceutically active compounds in the aquatic environment (2004) Critical Reviews in Toxicology, 34 (4), pp. 335-350. , DOI 10.1080/10408440490464697Morley, N.J., Environmental risk and toxicology of human and veterinary waste: Pharmaceutical exposure to aquatic host-parasite relationships (2009) Environ Toxicol Pharmacol, 27, pp. 161-175Ruhoy, I.S., Daughton, C.G., Beyond the medicine cabinet: An analysis of where and why medications accumulate (2008) Environ Internat, 34, pp. 1157-1169Ruhoy, I.S., Daughton, C.G., Types and quantities of leftover drugs entering the environment via disposal to sewage - Revealed by coroner records (2007) Sci Total Environ, 388, pp. 137-148Glassmmeyer, S.T., Hinchey, E.K., Boehme, S.E., Disposal practices for unwanted residential medications in the United States (2009) Environ Internat, 35 (3), pp. 566-572Ternes, T.A., Occurrence of drugs in Germany sewage treatment plants and rivers (1998) Water Res, 32, pp. 3245-3257Daugton, C.G., Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and Avenues toward a Green Pharmacy (2003) Environ Health Perspect, 111, pp. 757-774Daugton, C.G., Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. II. Drug disposal, waste reduction, and future directions (2003) Environ Health Perspect, 111, pp. 775-785Zhou, J.L., Zhang, Z.L., Banks, E., Grover, D., Jiang, J.Q., Pharmaceutical residues in wastewater treatment works effluents and their impact on receiving river water (2009) J Hazard Mater, 166, pp. 655-661Alonso, S.G., Catalá, M., Maroto, R.R., Gil, J.L.R., Miguel, A.G., Valcárcel, Y., Pollution by psychoative pharmaceuticals in the Rivers of Madrid metropolitan área (Spain) (2010) Environ Internat, 36, pp. 195-201Kolpin, D.W., Furlong, E.T., Meyer, M.T., Thurman, E.M., Zaugg, S.D., Barber, L.B., Buxton, H.T., Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance (2002) Environmental Science and Technology, 36 (6), pp. 1202-1211. , DOI 10.1021/es011055jLoraine, G.A., Pettigrove, M.E., Seasonal variations in concentrations of pharmaceuticals and personal care products in drinking water and reclaimed wastewater in Southern California (2006) Environmental Science and Technology, 40 (3), pp. 687-695. , DOI 10.1021/es051380xReif, R., Suárez, S., Omil, F., Lema, J.M., Fate of pharmaceuticals and cosmetic ingredients during the operation of a MBR treating sewage (2008) Desalination, 221, pp. 511-517Xu, J., Wu, L., Chang, A.C., Degradation and adsorption of selected pharmaceuticals and personal care products (PPCPs) in agricultural soils (2009) Chemosphere, 77, pp. 1299-1305Bound, J.P., Kitsou, K., Voulvoulis, N., Household disposal of pharmaceuticals and percepction of risk to the environment (2006) Environ Toxicol Pharmacol, 21, pp. 301-307Flaherty, C.M., Dodson, S.I., Effects of pharmaceuticals on Daphnia survival, growth, and reproduction (2005) Chemosphere, 61 (2), pp. 200-207. , DOI 10.1016/j.chemosphere.2005.02.016, PII S004565350500295XGhiselli, G., Jardim, W.F., Interferentes endócrinos no ambiente (2007) Química Nova, 30, pp. 695-706Silva, A.S., (2009) Interferentes Endócrinos No Meio Ambiente: Um Estudo de Caso Em Amostras de Água in Natura e Efluente Da Estação de Tratamento de Esgotos Da Região Metropolitana de São Paulo, , [Tese]. São Paulo (SP): Universidade de São Paulo, Faculdade de Saúde PúblicaSodré, F.F., Locatelli, M.A., Jardim, W.F., Occurrence of Emerging Contaminants in Brazilian Drinking Waters: A Sewage-To-Tap Issue (2010) Water Air Soil Pollut, 206, pp. 57-67Reynolds, K.A., Preocupación por la presencia de productos farmacêuticos en el água potable (2008) Água Latinoam, 8, pp. 16-18Martinez, J.L., Environmental pollution by antibiotics and by antibiotic resistance determinants (2009) Environ Pollut, 157, pp. 2893-2902Cunningham, V.L., Binks, S.P., Olson, M.J., Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment (2009) Regulat Toxicol Pharmacol, 53, pp. 39-45Kuspis, D.A., Krenzelok, E.P., What happens to expired medications? A survey of community medication disposal (1996) Veterinary and Human Toxicology, 38 (1), pp. 48-49Smart Disposal: A Prescription for a Healthy Planet, , http://www.smarxtdisposal.net/index.html, [homepage na Internet]. United States of America: Government Printing Office's Contracting Officer. [acesso em 2010 Jun 20]. Disponível emHow to Dispose of Unused Medicines, , http://www.fda.gov/downloads/Drugs/ResourcesForYou/Consumers/ BuyingUsingMedicineSafely/UnderstandingOver-the-CounterMedicines/ucm107163.pdf, [homepage na Internet]. United States of America: Consumer Health Information[atualizada em 2009 Outacesso em 2010 Jun 20] Disponível emSilva, E.R., (2005) Problematizando O Descarte de Medicamentos Vencidos: Para Onde Destinar?, , http://www.epsjv.fiocruz.br/beb/Monografias2005/evelyn.pdf, [monografia na Internet]. Rio de Janeiro: Fundação Oswaldo Cruz, Escola Politécnica de Saúde Joaquim Venâncio. Rio de Janeiro, [acesso em 2010 Jun 20]. Disponível emMelo, V., (2005) Descarte de Medicamentos Vencidos Por Usuários Residentes Na Cidade de São Paulo, , http://www.oswaldocruz.br/download/artigos/saude20.pdf, [artigo na Internet]. São Paulo: Faculdades Oswaldo Cruz. [acesso em 2010 Jun 20]. Disponível emKotchen, M., Kallaos, J., Wheeler, K., Wong, C., Zahller, M., Pharmaceuticals in wastewater: Behaviour, preferences, and willingness to pay for a disposal program (2009) J Environ Manag, 90, pp. 1476-1482Brandão, A., (2010) Um Remédio Chamado Solidariedade, , Pharmácia Brasileira abri/mai:21-6http://www2.portoalegre.rs.gov.br/dmlu/default.php?p_secao=96, [homepage na Internet]. Medicamentos Vencidos. Porto Alegre: DMLU. [acesso em 2010 Jun 20]. Disponível emhttp://blog.ftc.br/ftcverde/?tag=medicamentos-vencidos, [homepage na internet]. Descarte responsável de medicamentos vencidos. Salvador: Faculdade de Tecnologia e Ciências de Salvador. [atualizada em 2009 Set 28acesso em 2010 Jun 20]. Disponível em(2004) NBR 10.004 - Resíduos Sólidos: Classificação, , Associação Brasileira de Normas Técnicas Rio de Janeiro: ABNT(2004) Dispõe Sobre O Regulamento Técnico para O Gerenciamento de Resíduos de Serviços de Saúde, , Brasil. Resolução ANVISA RDC n. 306, de 7 de dezembro de 2004 Brasília: Ministério da Saúde(2005) Dispõe Sobre O Tratamento e a Disposição Final Dos Resíduos de Serviços de Saúde e Dá Outras Providências, , Brasil. Resolução CONAMA n. 358, de 29 de abril de 2005 Brasília: Ministério do Meio Ambiente(1998) Aprova O Regulamento Técnico Sobre Substâncias e Medicamentos Sujeitos a Controle Especial, , Brasil. Portaria MS n. 344, de 12 de maio de 1998 Brasília: Ministério da Saúde(2001) Dispõe Sobre O Tratamento e a Destinação Final Dos Resíduos de Serviços de Saúde, , Brasil. Resolução CONAMA n. 283, de 12 de julho de 2001 Brasília: Ministério do Meio Ambiente(2008) Aprova a Norma Técnica Sobre Gerenciamento de Resíduos Perigosos de Medicamentos Em Serviços de Saúde, , São Paulo. Portaria CVS n. 21, de 10 de setembro de São Paulo: Secretaria de Estado de Saúde(2007) Resíduos e Gestão Ambiental, , Conselho Regional de Farmácia do Estado de São Paulo São Paulo: CRF, abril(2010) Pesquisa Nacional de Saneamento Básico 2008, , IBGE (Instituto Brasileiro de Geografia e Estatística) Rio de Janeiro: IBGE