Identification Of Target Genes Using Gene Expression Profile Of Granulocytes From Patients With Chronic Myeloid Leukemia Treated With Tyrosine Kinase Inhibitors

dc.creatorMascarenhas C.D.C.
dc.creatorFerreira Da Cunha A.
dc.creatorBrugnerotto A.F.
dc.creatorGambero S.
dc.creatorDe Almeida M.H.
dc.creatorCarazzolle M.F.
dc.creatorPagnano K.B.B.
dc.creatorTraina F.
dc.creatorCosta F.F.D.
dc.creatorDe Souza C.A.
dc.date2014
dc.date2015-06-25T17:50:54Z
dc.date2015-11-26T15:38:13Z
dc.date2015-06-25T17:50:54Z
dc.date2015-11-26T15:38:13Z
dc.date.accessioned2018-03-28T22:46:43Z
dc.date.available2018-03-28T22:46:43Z
dc.identifier
dc.identifierLeukemia And Lymphoma. Informa Healthcare, v. 55, n. 8, p. 1861 - 1869, 2014.
dc.identifier10428194
dc.identifier10.3109/10428194.2013.855311
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84904900099&partnerID=40&md5=31a1a5441939a95c0e8f7c92d4d234a2
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85933
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85933
dc.identifier2-s2.0-84904900099
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1263851
dc.descriptionDifferential gene expression analysis by suppression subtractive hybridization with correlation to the metabolic pathways involved in chronic myeloid leukemia (CML) may provide a new insight into the pathogenesis of CML. Among the overexpressed genes found in CML at diagnosis are SEPT5, RUNX1, MIER1, KPNA6 and FLT3, while PAN3, TOB1 and ITCH were decreased when compared to healthy volunteers. Some genes were identified and involved in CML for the first time, including TOB1, which showed a low expression in patients with CML during tyrosine kinase inhibitor treatment with no complete cytogenetic response. In agreement, reduced expression of TOB1 was also observed in resistant patients with CML compared to responsive patients. This might be related to the deregulation of apoptosis and the signaling pathway leading to resistance. Most of the identified genes were related to the regulation of nuclear factor κB (NF-κB), AKT, interferon and interleukin-4 (IL-4) in healthy cells. The results of this study combined with literature data show specific gene pathways that might be explored as markers to assess the evolution and prognosis of CML as well as identify new therapeutic targets. © 2014 Informa UK, Ltd.
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dc.languageen
dc.publisherInforma Healthcare
dc.relationLeukemia and Lymphoma
dc.rightsfechado
dc.sourceScopus
dc.titleIdentification Of Target Genes Using Gene Expression Profile Of Granulocytes From Patients With Chronic Myeloid Leukemia Treated With Tyrosine Kinase Inhibitors
dc.typeArtículos de revistas


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