T Allele Of -344c/t Polymorphism In Aldosterone Synthase Gene Is Not Associated With Resistant Hypertension

dc.creatorLacchini R.
dc.creatorSabha M.
dc.creatorCoeli F.B.
dc.creatorFavero F.F.
dc.creatorYugar-Toledo J.
dc.creatorIzidoro-Toledo T.C.
dc.creatorSandrim V.C.
dc.creatorTanus-Santos J.E.
dc.creatorde Mello M.P.
dc.creatorMoreno Jr. H.
dc.date2009
dc.date2015-06-26T13:37:03Z
dc.date2015-11-26T15:37:47Z
dc.date2015-06-26T13:37:03Z
dc.date2015-11-26T15:37:47Z
dc.date.accessioned2018-03-28T22:46:12Z
dc.date.available2018-03-28T22:46:12Z
dc.identifier
dc.identifierHypertension Research. , v. 32, n. 2, p. 159 - 162, 2009.
dc.identifier9169636
dc.identifier10.1038/hr.2008.36
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-67651106535&partnerID=40&md5=3ca5b5599620836fab78249e13a02043
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/92674
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/92674
dc.identifier2-s2.0-67651106535
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1263731
dc.descriptionResistant hypertension (RH) is the maintenance of elevated blood pressure concurrent with the use of three different anti-hypertensive drugs, one of which is a diuretic. The Renin-Angiotensin-Aldosterone System plays a major role in volume-dependent hypertension. Therefore, its components are interesting targets for genetic association studies. This work focused on the -344 C/T polymorphism in the CYP11b2 gene, which encodes aldosterone synthase. This work evaluates the association between T allele and resistance to anti-hypertensive treatment. Genotyping analysis included 88 subjects with RH, 142 who were responsive to anti-hypertensive treatment and 110 subjects as a control group. Plasmatic concentrations of aldosterone, renin and cortisol, carotid intima-media thickness and carotid-femoral pulse wave velocity were assessed in a smaller subset of hypertensive patients. An association was found between T allele and hypertension (P<0.005), but there was no difference in allele frequencies between both hypertensive groups. There was no difference in plasmatic parameters either, in remodeling indicators between the genotypic groups.
dc.description32
dc.description2
dc.description159
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dc.languageen
dc.publisher
dc.relationHypertension Research
dc.rightsfechado
dc.sourceScopus
dc.titleT Allele Of -344c/t Polymorphism In Aldosterone Synthase Gene Is Not Associated With Resistant Hypertension
dc.typeArtículos de revistas


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