Artículos de revistas
Proparacaine Complexation With β-cyclodextrin And P-sulfonic Acid Calix[6]arene, As Evaluated By Varied 1h-nmr Approaches
Registro en:
Magnetic Resonance In Chemistry. , v. 47, n. 9, p. 757 - 763, 2009.
7491581
10.1002/mrc.2460
2-s2.0-68649101487
Autor
Arantes L.M.
Scarelli C.
Marsaioli A.J.
De Paula E.
Fernandes S.A.
Institución
Resumen
This study focused on the use of NMR techniques as a tool for the investigation of complex formation between proparacaine and cyclodextrins (CDs) or p-sulfonic acid calix[6]arene. The pHdependence of the complexation of proparacainewith β-CD and p-sulfonic acid calix[6]arene was studied and binding constants were determined by 1H NMR spectroscopy [diffusion-ordered spectroscopy (DOSY)] for the charged and uncharged forms of the local anesthetic in β-CD and p-sulfonic acid calix[6]arene. The stoichiometries of the complexes was determined and rotating frame Overhauser enhancement spectroscopy (ROESY) 1D experiments revealed details of themolecular insertion of proparacaine into the β-CD and p-sulfonic acid calix[6]arene cavities. The results unambiguously demonstrate that pH is an important factor for the development of supramolecular architectures based on β-CD and p-sulfonic acid calix[6]arene as the host molecules. 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