A Simple And Portable Instrument For Determination Of Captopril In Pharmaceutical Formulations

dc.creatorRibeiro P.R.S.
dc.creatorPezza H.R.
dc.creatorPezza L.
dc.creatorTubino M.
dc.date2014
dc.date2015-06-25T17:50:45Z
dc.date2015-11-26T15:36:51Z
dc.date2015-06-25T17:50:45Z
dc.date2015-11-26T15:36:51Z
dc.date.accessioned2018-03-28T22:45:19Z
dc.date.available2018-03-28T22:45:19Z
dc.identifier
dc.identifierInternational Journal Of Pharmacy And Pharmaceutical Sciences. Ijpps, v. 6, n. 4, p. 194 - 198, 2014.
dc.identifier9751491
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84899793587&partnerID=40&md5=04320f5e60429dfe597c07be1ddb1e68
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85903
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85903
dc.identifier2-s2.0-84899793587
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1263529
dc.descriptionObjective: This article describes the application and the performance of a cheap, simple and portable device that can be used for colorimetric quantitative determination of captopril (CPT) in pharmaceutical preparations. Methods: The sensor is a light detector resistor (LDR) placed into a black PTFE cell and coupled to a low cost multimeter (Ohmmeter). The instrument has been tested and is easy and fast to use. The quantitative study is based mainly on reduction of ammonium molybdate by captopril, in the presence of sulphuric acid, producing a green-yellow compound (λmax 407 nm). The calibration curves were obtained by plotting the electric resistance of the LDR against the CPT concentration on the range of 4.60 × 10-4 to 1.84 × 10-3 mol l-1 with a good coefficient of determination (R2 = 0.9962). Results: Statistical analysis of the obtained results showed no significant difference between the proposed methodology and the official reported method as evident from the t-test and variance ratio at 95% confidence level. Conclusion: The results of this study demonstrate that the instrument can be used for simple, accurate, precise, fast, in situ and low-cost colorimetric analysis of captopril in pharmaceuticals products.
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dc.languageen
dc.publisherIJPPS
dc.relationInternational Journal of Pharmacy and Pharmaceutical Sciences
dc.rightsfechado
dc.sourceScopus
dc.titleA Simple And Portable Instrument For Determination Of Captopril In Pharmaceutical Formulations
dc.typeArtículos de revistas


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