dc.creator | Escobar E.L.O. | |
dc.creator | Gomes-Marcondes M.C.C. | |
dc.creator | Carvalho H.F. | |
dc.date | 2009 | |
dc.date | 2015-06-26T13:36:28Z | |
dc.date | 2015-11-26T15:36:47Z | |
dc.date | 2015-06-26T13:36:28Z | |
dc.date | 2015-11-26T15:36:47Z | |
dc.date.accessioned | 2018-03-28T22:45:15Z | |
dc.date.available | 2018-03-28T22:45:15Z | |
dc.identifier | | |
dc.identifier | Prostate. , v. 69, n. 5, p. 548 - 558, 2009. | |
dc.identifier | 2704137 | |
dc.identifier | 10.1002/pros.20905 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-61949483298&partnerID=40&md5=198b11b5b54dab3f3a46a6f7941f1db2 | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/92550 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/92550 | |
dc.identifier | 2-s2.0-61949483298 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1263513 | |
dc.description | BACKGROUND. Fatty acids are among the most important nutritional factors associated with the ethiopathogenesis of prostate cancer, therefore the main objective of this work was to evaluate the effect of quality of fatty acid on the rat ventral prostate growth, tissue organization, and expression of androgen receptor (AR) and peroxisome proliferation activator receptor g (PPARγ). METHODS. Wistar rats were distributed into five groups, which were fed isocaloric normolipidic diets containing soybean oil (7% Control), linseed (7% or 3.5% linseed plus 3.5% soybean oil) and rendered pork fat (7% or 3.5% lard plus 3.5% soybean oil) for 10 weeks after weaning. RESULTS. At the end of treatment, the experiments demonstrated that lard and linseed oil caused opposite effects on prostatic growth. While the lard promoted an increase in prostatic weight associated to epithelial hyperplasia (confirmed by stereology); the linseed resulted in a significantly lighter organ. Immunohistochemistry and Western blotting demonstrated increased expression of AR and PPARγ in groups fed with lard diet, while linseed oil promoted a decrease. CONCLUSIONS. Prostatic growth is influenced by dietary fatty acids with concurrent variation in the expression of AR and PPARγ. PPARγ might represent the link between diet and prostate growth and AR expression and function. Since the levels of testosterone were altered it is also possible that prostatic changes are secondary to systemic effects of the diet. © 2009 Wiley-Liss, Inc. | |
dc.description | 69 | |
dc.description | 5 | |
dc.description | 548 | |
dc.description | 558 | |
dc.description | Dhom, G., Epidemiologic aspects of latent and clinically manifest carcinoma of the prostate (1983) Journal of Cancer Research and Clinical Oncology, 106 (3), pp. 210-218 | |
dc.description | Chaudry, A., McClinton, S., Moffat, L.E.F., Wahle, K.W.J., Essential fatty acids distribution in the plasma and tissue phospholipids of patients with benign and malignant prostatic disease (1991) Br J Cancer, 64, pp. 1157-1160 | |
dc.description | Rowley, K.H., Mason, M.D., The aetiology and patogenesis of prostate cancer (1997) Clin Oncol R Coll Radiol, 9, pp. 213-218 | |
dc.description | Mamalakis, G., Kafatos, A., Karagelopoulos, N., Andrikolopoulos, N., Daskalopoulos, G., Kranidis, A., Prostate cancer vs hiperplasia: Relationships with prostatic and adipose tissue fatty acid composition (2002) Prostagl Leukotr Essent Fatty Acids, 66, pp. 467-477 | |
dc.description | Hankey, B.F., Feuer, E.J., Clegg, L.X., Hayes, R.B., Legler, J.M., Prorok, P.C., Ries, L.A., Kaplan, R.S., Cancer surveillance series: Interpreting trends in prostate cancer. Part I. Evidence of the effects of screening in recent prostate cancer incidence, mortality, and survival rates (1999) J Natl Cancer Inst, 91, pp. 1017-1024 | |
dc.description | Fleshner, N., Bagnell, P.S., Klotz, L., Venkateswaran, V., Kristal, A.R., Thompson, I.M., Klein, E., Ford, L.G., Dietary fat and prostate cancer (2004) Journal of Urology, 171 (2), pp. S19-S24. , DOI 10.1097/01.ju.0000107838.33623.19 | |
dc.description | Shennan, D.H., Bishop, O.S., Diet and the mortality from malignant disease in 32 countries (1974) West Indian Med J, 23, pp. 44-53 | |
dc.description | Blair, A., Fraumeni Jr., J.F., Geographic patterns of prostate cancer in the United States (1978) Journal of the National Cancer Institute, 61 (6), pp. 1379-1384 | |
dc.description | Carroll, K.K., Khor, H.T., Dietaty fat in relation to tumorigenesis (1975) Prog Biochem Pharmacol, 10, pp. 308-353 | |
dc.description | Kolonel, L.N., Nomura, A.M., Cooney, R.V., Dietary fat and prostate cancer: Current status (1999) J Natl Cancer Inst, 91, pp. 414-428 | |
dc.description | Myers, C.E., Ghosh, J., Lipoxygenase inhibition in prostate cancer (1999) European Urology, 35 (5-6), pp. 395-398. , DOI 10.1159/000019915 | |
dc.description | Zhu, Y.S., Katz, M.D., McGinley, I., Lessons from human genetic models (1998) Bailleres Clin Endocrinol Metab, 12, pp. 83-113 | |
dc.description | Cunha, G.R., Donjacour, A.A., Cooke, P.S., Mee, S., Bigsby, R.M., Higgins, S.J., Sugimura, Y., The endocrinology and developmental biology of the prostate (1987) Endocr Rev, 8, pp. 338-362 | |
dc.description | Ross, R.K., Henderson, B.E., Do diets and androgens alter prostate cancer risk via a common etiologic pathway? (1994) J Natl Cancer Inst, 86, pp. 252-254 | |
dc.description | Dorgan, J.F., Judd, J.T., Longcope, C., Brown, C., Schatzkin, A., Clevidence, B.A., Campbell, W.S., Taylor, P.R., Effects of dietary fat and fiber on plasma and urine androgens and estrogens in men: A controlled feeding study (1996) Am J Clin Nutr, 64, pp. 850-855 | |
dc.description | Issemann, I., Green, S., Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators (1990) Nature, 347 (6294), pp. 645-650. , DOI 10.1038/347645a0 | |
dc.description | Zhang, B., Marcus, S.L., Sajjadi, F.G., Alvares, K., Reddy, J.K., Subramani, S., Rachubinski, R.A., Capone, J.P., Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase 3-hydroxyacyl-CoA- dehydrogenase (1992) Proc Natl Acad Sci USA, 89, pp. 7541-7545 | |
dc.description | Krey, G., Braissant, O., L'Horset, F., Kalkhoven, E., Perroud, M., Parker, M.G., Wahli, W., Fatty acids eicosanoids are ligands for peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay (1997) Mol Endocrinol, 11, pp. 770-791 | |
dc.description | Segawa, Y., Yoshimura, R., Hase, T., Hase, T., Nakatani, T., Wada, S., Kawahito, Y., Sano, H., Expression of peroxisome proliferator-activated receptor (PPAR) in human prostate cancer (2002) Prostate, 51, pp. 108-116 | |
dc.description | Willson, T.M., Lambert, M.H., Kliewer, S.A., Peroxisome proliferator-activated receptor gamma and metabolic disease (2001) Annual Review of Biochemistry, 70, pp. 341-367. , DOI 10.1146/annurev.biochem.70.1.341 | |
dc.description | Sporn, M.B., Suh, N., Mangelsdorf, D.J., Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs) (2001) Trends in Molecular Medicine, 7 (9), pp. 395-400. , DOI 10.1016/S1471-4914(01)02100-1, PII S1471491401021001 | |
dc.description | Rosen, E.D., Spiegelman, B.M., PPARgamma: A Nuclear Regulator of Metabolism, Differentiation, and Cell Growth (2001) Journal of Biological Chemistry, 276 (41), pp. 37731-37734 | |
dc.description | Nwankwo, J.O., Robbins, M.E.C., Peroxisome proliferator-activated receptor-gamma expression in human malignant and normal brain, breast and prostate-derived cells (2001) Prostaglandins Leukotrienes and Essential Fatty Acids, 64 (4-5), pp. 241-245. , DOI 10.1054/plef.2001.0266 | |
dc.description | Han, S., Roman, J., Peroxisome proliferator-activated receptor gamma: A novel target for cancer therapeutics? (2007) Anticancer Drugs, 18 (3), pp. 237-244 | |
dc.description | Mueller, E., Smith, M., Sarraf, P., Kroll, T., Aiyer, A., Kaufman, D.S., Oh, W., Kantoff, P.W., Effects of ligand activation of peroxisome proliferator-activated receptor g human prostate cancer (2000) Proc Natl Acad Sci USA, 97, pp. 10990-10995 | |
dc.description | Buyukbabani, N., Mitchell, S.H., Tindall, D.J., Young, C.Y.F., Non-apoptotic cell death associated with S-phase arrest of prostate cancer cells via peroxisome proliferator-activated receptor γ ligand, 15-deoxy-12,14-prostaglandin J12 (2000) Cell Growth Differ, 11, pp. 49-61 | |
dc.description | Li, W.-D., Lee, J.H., Price, R.A., The peroxisome proliferator-activated receptor gamma2 Pro12Ala mutation is associated with early onset extreme obesity and reduced fasting glucose (2000) Molecular Genetics and Metabolism, 70 (2), pp. 159-161. , DOI 10.1006/mgme.2000.2999 | |
dc.description | Reeves, P.G., Nielsen, F.H., Fahey Jr., G.C., AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet (1993) J Nutr, 123, pp. 1939-1951 | |
dc.description | Kondo, Y., Homma, Y., Aso, Y., Kakizoe, T., Promotional effect of two-generation exposure to a high-fat diet on prostate carcinogenesis in ACI/Seg rats (1994) Cancer Research, 54 (23), pp. 6129-6132 | |
dc.description | Wang, Y., Corr, J.G., Thaler, H.T., Tao, Y., Fair, W.R., Heston, W.D., Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet (1995) J Natl Cancer Inst, 87, pp. 1456-1462 | |
dc.description | Garcia-Florez, M., Oliveira, C.A., Carvalho, H.F., Early effects of estrogen on the rat ventral prostate (2005) Brazilian Journal of Medical and Biological Research, 38 (4), pp. 487-497 | |
dc.description | Vilamaior, P.S.L., Taboga, S.R., Carvalho, H.F., Postnatal growth of the ventral prostate in Wistar rats: A stereological and morphometrical study (2006) Anat Rec, 288 A, pp. 885-892 | |
dc.description | Fritz, W.A., Wang, J., Eltoum, I.-E., Lamartiniere, C.A., Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate (2002) Molecular and Cellular Endocrinology, 186 (1), pp. 89-99. , PII S0303720701006633 | |
dc.description | Gad, S.C., Weil, C.S., Statistic for toxicologists (1994) Principles and Methods of Toxicology, pp. 221-274. , Wallace H, editor. New York: Raven Press | |
dc.description | Giles, G., Ireland, P., Diet, nutrition and prostate cancer (1997) International Journal of Cancer, 72 (SUPPL.), pp. 13-17 | |
dc.description | Cai, X., Haleem, R., Oram, S., Cyriac, J., Jiang, F., Grayhack, J.T., Kozlowski, J.M., Wang, Z., High fat diet increases the weight of rat ventral prostate (2001) Prostate, 49 (1), pp. 1-8. , DOI 10.1002/pros.1112 | |
dc.description | Cai, G., Huang, H., Shapiro, E., Zhou, H., Yeh, S., Melamed, J., Greco, M.A., Lee, P., Expression of androgen receptor associated protein 55 (ARA55) in the developing human fetal prostate (2005) Journal of Urology, 173 (6), pp. 2190-2193. , DOI 10.1097/01.ju.0000158119.34126.70 | |
dc.description | Wahle, K.W., Heys, S.D., Cell signal mechanisms, conjugated linoleic acids (CLAs) and anti-tumorigenesis (2002) Prostagl Leukotr Essent Fatty Acids, 67, pp. 183-186 | |
dc.description | Bidoli, E., Talamini, R., Bosetti, C., Negri, E., Maruzzi, D., Montella, M., Franceschi, S., La Vecchia, C., Macronutrients, fatty acids, cholesterol and prostate cancer risk (2005) Ann Oncol, 16, pp. 152-157 | |
dc.description | Feldman, B.J., Feldman, D., The development of androgen-independent prostate cancer (2001) Nature Reviews Cancer, 1 (1), pp. 34-45 | |
dc.description | Sciarra, F., Toscano, V., Role of estrogens in human benign prostatic hyperplasia (2000) Archives of Andrology, 44 (3), pp. 213-220 | |
dc.description | Håå G, P., Bektic, J., Bartsch, G., Klocker, H., Eder, I.E., Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells (2005) J Steroid Biochem Mol Biol, 96, pp. 251-258 | |
dc.description | Freeman, V.L., Meydani, M., Hur, K., Flanigan, R.C., Inverse association between prostatic polyunsaturated fatty acid and risk of locally advanced prostate carcinoma (2004) Cancer, 101 (12), pp. 2744-2754. , DOI 10.1002/cncr.20676 | |
dc.description | Bravi, F., Bosetti, C., Dal Maso, L., Talamini, R., Montella, M., Negri, E., Ramazzotti, V., La Vecchia, C., Food groups and risk of benign prostatic hyperplasia (2006) Urology, 67 (1), pp. 73-79. , DOI 10.1016/j.urology.2005.07.030, PII S009042950501126X | |
dc.description | Hardman, W.E., (n-3) fatty acids and cancer therapy (2004) J Nutr, 134 (12 SUPPL.), pp. 3427S-3430S | |
dc.description | Kota, B.P., Huang, T.H.-W., Roufogalis, B.D., An overview on biological mechanisms of PPARs (2005) Pharmacological Research, 51 (2), pp. 85-94. , DOI 10.1016/j.phrs.2004.07.012, PII S104366180400194X | |
dc.description | Subbarayan, V., Sabichi, A.L., Kim, J., Llansa, N., Logothetis, C.J., Lippman, S.M., Menter, D.G., Differential peroxisome proliferator-activated receptor-γ isoform expression and agonist effects in normal and malignant prostate cells (2004) Cancer Epidemiology Biomarkers and Prevention, 13 (11), pp. 1710-1716 | |
dc.description | Cury-Boaventura, F.M., Kanunfre, C.C., Gorjão, R., Martins De Lima, T., Curi, R., Mechanisms involved in Jurkat cell death induced by oleic and linoleic acids (2006) Clin Nutr, 25, pp. 1004-1014 | |
dc.description | Sampath, H., Ntambi, J.M., Polyunsaturated fatty acid regulation of gene expression (2004) Nutrition Reviews, 62 (9), pp. 333-339. , DOI 10.1301/nr.2004.sept.333-339 | |
dc.description | Murtaugh, M.A., Ma, K.-N., Caan, B.J., Sweeney, C., Wolff, R., Samowitz, W.S., Potter, J.D., Slattery, M.L., Interactions of peroxisome proliferator-activated receptor, and diet in etiology of colorectal cancer (2005) Cancer Epidemiology Biomarkers and Prevention, 14 (5), pp. 1224-1229. , DOI 10.1158/1055-9965.EPI-04-0681 | |
dc.language | en | |
dc.publisher | | |
dc.relation | Prostate | |
dc.rights | fechado | |
dc.source | Scopus | |
dc.title | Dietary Fatty Acid Quality Affects Ar And Pparγ Levels And Prostate Growth | |
dc.type | Artículos de revistas | |