Objectives: To analyze concordance between preoperative lymphoscintigraphy and intraoperative lymphatic mapping (ILM) for sentinel lymph node identification using technetium 99m-labeled-dextran 500 (99m-Tc) and patent blue dye in patients with early cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy, as well as to evaluate sentinel lymph node (SLN) detection. Study design: Forty-seven patients underwent surgical treatment for cervical cancer. For SLN identification, 99m-Tc and blue patent were injected into the cervix on the eve and day of surgery, respectively. Preoperative pelvic lymphoscintigraphy was performed in all patients after 99m-Tc injection. Concordance between preoperative lymphoscintigraphy and ILM was evaluated. Results: Of the 56 patients who underwent preoperative lymphoscintigraphy, 43 (81.13%) had at least one lymph node identified. Bilateral lymph nodes were identified in 21 (37.5%) patients. Sentinel lymph nodes detected on ILM had been previously found on preoperative lymphoscintigraphy in 66.7%, 67.2% and 0% in the right, left and central locations, respectively. In 14 patients (25%), only one lymph node was identified on preoperative lymphoscintigraphy, but more than one sentinel lymph node was detected on intraoperative mapping. In nine (16.1%) patients, lymphoscintigraphy showed only unilateral lymph nodes, but ILM identified bilateral sentinel lymph nodes. Conclusion: The combination of patent blue and radionuclide techniques produced excellent results for SLN detection in cervical cancer. Preoperative lymphoscintigraphy does not offer any advantage over ILM for SLN identification. © 2009 Elsevier Ireland Ltd. All rights reserved.14519699Malur, S., Krause, N., Köhler, C., Scheneider, A., Sentinel lymph node detection in patients with cervical cancer (2001) Gynecol Oncol, 80, pp. 254-257Silva, L.B., Silva-Filho, A.L., Traiman, P., Sentinel node detection in cervical cancer with 99mTc-phytate (2005) Gynecol Oncol, 97 (2), pp. 588-595Di Stefano, A.B., Acquaviva, G., Garozzo, G., Lymph node mapping and sentinel node detection in patients with cervical carcinoma: a 2-year experience (2005) Gynecol Oncol, 99, pp. 671-679Niikura, H., Okamura, C., Akahira, J., Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blue (2004) Gynecol Oncol, 94, pp. 528-532Lande, J., Torrenga, B., Raijmakers, P.G.H.M., Sentinel lymph node detection in early stage uterine cervix carcinoma: a systematic review (2007) Gynecol Oncol, 106, pp. 604-613Frumovitz, M., Coleman, R.L., Gayed, I.W., Usefulness of preoperative lymphoscintigraphy in patients who undergo radical hysterectomy and pelvic lymphadenectomy for cervical cancer (2006) Am J Obstet Gynecol, 194, pp. 1186-1195Vieira, S.C., Zeferino, L.C., Silva, B.B., Estudo do linfonodo sentinela no câncer do colo uterino com azul patente (2004) Rev Asoc Med Brasil, 50 (3), pp. 302-304Plante, M., Renaud, M.C., Têtu, B., Harel, F., Roy, M., Laparoscopic sentinel node mapping in early-stage cervical cancer (2003) Gynecol Oncol, 91, pp. 494-503Hauspy, J., Verkinderen, L., De Pooter, C., Dirix, L.Y., van Dam, P.A., Sentinel node metastasis in the groin detected by technetium-labeled nanocolloid in a patient with cervical cancer (2002) Gynecol Oncol, 86 (3), pp. 358-360Pijpers, R., Buist, M.R., van Lingen, A., The sentinel node in cervical cancer: scintigraphy and laparoscopic gamma probe-guided biopsy (2004) Eur J Nucl Med Mol Imaging, 31, pp. 1479-1486Morton, D.L., Wen, D.R., Wong, J.H., Technical details of intraoperative lymphatic mapping for early stage melanoma (1992) Arch Surg, 127, pp. 392-399Ayhan, A., Celik, H., Dursun, P., Lymphatic mapping and sentinel node biopsy in gynecological cancers: a critical review of the literature (2008) World J Surg Oncol, 6, p. 53Bats, A., Lavoué, V., Rouzier, R., Coutant, C., Kerrou, K., Daraï, E., Limits of day-before lymphoscintigraphy to localize sentinel nodes in women with cervical cancer (2008) Ann Surg Oncol, 15 (8), pp. 2173-2179Lavoué, V., Bats, A., Rouzier, R., Coutant, C., Barranger, E., Daraï, E., Sentinel lymph node procedure followed by laparoscopic pelvic and paraaortic lymphadenectomy in women with IB2-II cervical cancer (2007) Ann Surg Oncol, 14 (9), pp. 2654-2661Kara, P.P., Ayhan, A., Caner, B., Sentinel lymph node detection in early stage cervical cancer: a prospective study comparing preoperative lymphoscintigraphy, intraoperative gamma probe, and blue dye (2008) Ann Nucl Med, 22 (6), pp. 487-494Altgassen, C., Hertel, H., Brandstädt, A., Köhler, C., Dürst, M., Schneider, A., Multicenter validation study of the sentinel lymph node concept in cervical cancer: AGO Study Group (2008) J Clin Oncol, 26 (18), pp. 2943-2951