Islet Neogenesis-associated Protein Pentadecapeptide (ingap-pp): Mechanisms Involved In Its Effect Upon β-cell Mass And Function

dc.creatorMadrid V.
dc.creatorDel Zotto H.
dc.creatorMaiztegui B.
dc.creatorRaschia M.A.
dc.creatorAlzugaray M.E.
dc.creatorBoschero A.C.
dc.creatorBarbosa H.C.
dc.creatorFlores L.E.
dc.creatorBorelli M.I.
dc.creatorGagliardino J.J.
dc.date2009
dc.date2015-06-26T13:36:22Z
dc.date2015-11-26T15:36:20Z
dc.date2015-06-26T13:36:22Z
dc.date2015-11-26T15:36:20Z
dc.date.accessioned2018-03-28T22:44:51Z
dc.date.available2018-03-28T22:44:51Z
dc.identifier
dc.identifierRegulatory Peptides. , v. 157, n. 1-3, p. 25 - 31, 2009.
dc.identifier1670115
dc.identifier10.1016/j.regpep.2009.05.011
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-68349097448&partnerID=40&md5=a0518b3cd420aef7275140bfaaf69a0a
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/92513
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/92513
dc.identifier2-s2.0-68349097448
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1263422
dc.descriptionThe effect of islet neogenesis-associated protein pentadecapeptide (INGAP-PP) administration to normal male hamsters upon serum glucose and triglyceride levels, β-cell mass and function was studied. INGAP-PP (500 μg) or saline was injected twice daily during 10 days. Both groups showed comparable body weight, serum glucose and triglyceride levels. INGAP-PP treated animals had significantly higher HOMA-IR and HOMA-β and their islets released more insulin in response to glucose; they had lower islet DNA content, significantly increased number of islets/unit area, β-cell replication rate and mass, cells co-expressing Pdx-1/INGAP and islets in contact with ducts, and decreased β-cell apoptosis rate. The percentage of cells expressing Pdx-1 alone or together with INGAP or insulin increased significantly in ducts. These animals also showed a significantly higher concentration of Pdx-1 and Ngn-3 mRNA and a lower number of INGAP-positive cells. In conclusion, INGAP-PP promoted a controlled and functionally active increase of β-cell mass; our data demonstrate for the first time the mechanism responsible for such changes; that Ngn-3 would be involved in INGAP-PP-induced neogenesis; and the existence of a negative feedback loop with endogenous INGAP-producing cells. Accordingly, INGAP-PP could be used to induce these effects in people with or at risk of developing diabetes. © 2009 Elsevier B.V. All rights reserved.
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dc.languageen
dc.publisher
dc.relationRegulatory Peptides
dc.rightsfechado
dc.sourceScopus
dc.titleIslet Neogenesis-associated Protein Pentadecapeptide (ingap-pp): Mechanisms Involved In Its Effect Upon β-cell Mass And Function
dc.typeArtículos de revistas


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