Morphology Of Temperature-sensitive And Ph-responsive Ipn-hydrogels For Application As Biomaterial For Cell Growth [morfologia De Hidrogéis-ipn Termo-sensíveis E Ph-responsivos Para Aplica ção Como Biomaterial Na Cultura De Células]

dc.creatorRubira A.F.
dc.creatorMuniz E.C.
dc.creatorGuilherme M.R.
dc.creatorPaulino A.T.
dc.creatorTambourgi E.B.
dc.date2009
dc.date2015-06-26T13:36:10Z
dc.date2015-11-26T15:35:57Z
dc.date2015-06-26T13:36:10Z
dc.date2015-11-26T15:35:57Z
dc.date.accessioned2018-03-28T22:44:29Z
dc.date.available2018-03-28T22:44:29Z
dc.identifier
dc.identifierPolimeros. , v. 19, n. 2, p. 105 - 110, 2009.
dc.identifier1041428
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-69549111381&partnerID=40&md5=147d5145a4dd8153497d33e94e942642
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/92450
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/92450
dc.identifier2-s2.0-69549111381
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1263334
dc.descriptionIn the present investigation, hydrogels with pH-responsive and temperature-sensitive properties were obtained by formation of alginate-Ca network inside the PNIPAAm network resulting in an interpenetrated network system (IPN). From scanning electron microscopy (SEM) images and water uptake (WU) tests one observed that IPN hydrogels exhibited a drastic shrinking when heated above 30-35°C. The shrinking resulted in decreased average pore size, thus affect the hydrogel morphology significantly. In the pH range studied, IPN hydrogels showed significant pH dependence, which was attributed to the charged alginate groups. The results indicated that the pH-responsiveness and temperature-dependence of alginate and PNIPAAm, respectively, were preserved in IPN hydrogels. In addition, such hydrogels become less deformable when subjected to compressive stress. These hydrogels presented porous morphology that may be tuned by controlling the temperature, and this makes them attractive for applications as biomaterial in cell growth.
dc.description19
dc.description2
dc.description105
dc.description110
dc.descriptionWang, X., Spencer, G., (1998) Polymer, 39, p. 2759
dc.descriptionMeeuse, B.J.D., (1962) Composition of Cell and Metabolic Products, , University of Washington, Washington
dc.descriptionDraget, K.I., Skjåk-Braek, G., Smidsrød, O., (1997) Inter. J. Biol. Macromol., 21, p. 47
dc.descriptionHalder, A., Maiti, S., Sa, B., (2005) Inter. J. Pharm., 302, p. 84
dc.descriptionShapiro, L., Cohen, S., (1997) Biomaterials, 18, p. 583
dc.descriptionLi, S., Wang, X.T., Zhang, X.B., Yang, R.J., Zhang, H.Z., Zhu, L.Z., Hou, X.P., (2002) J. Control. Release, 84, p. 87
dc.descriptionHurteaux, R., Edwards-Lévy, F., Laurent-Maquin, D., Lévy, M.C., (2005) Eur. J. Pharm. Sci., 24, p. 187
dc.descriptionChretien, C., Chaumeil, J.C., (2005) Inter. J. Pharm., 304, p. 18
dc.descriptionLiu, L., Sheardown, H., (2005) Biomaterials, 26, p. 233
dc.descriptionCho, J.H., Kim, S.H., Park, K.D., Jung, M.C., Yang, W.I., Han, S.W., Noh, J.Y., Lee, J.W.J.W., (2004) Biomaterials, 25, p. 5743
dc.descriptionKavanagh, C.A., Rochev, Y.A., Gallagher, W.M., Dawson, K.A., Keenan, A.K., (2004) Pharmacol & Therapeutics, 102, p. 1
dc.descriptionGuilherme, M.R., Reis, A.V., Rubira, A.F., Muniz, E.C., (2005), www.inpi.gov.br, PI 0503651-8, BrazilGuilherme, M.R., Campese, G.M., Radovanovic, E., Rubira, A.F., Tambourgi, E.B., Muniz, E.C., (2006) J. Membrane Sci., 275, p. 187
dc.descriptionSchild, H.G., (1992) Prog. Polym. Sci., 17, p. 163
dc.descriptionTakigawa, T., Yamawaki, T., Takahashia, K., Masuda, T., (1997) Polym. Gels Networks, 5, p. 585
dc.descriptionAthawale, V.D., Raut, S.S., (2002) Eur. Polym. J., 38, p. 2033
dc.descriptionJin, S.P., Liu, M.Z., Chen, S.L., Bian, F.L., Chen, Y., Wang, B., Zhan, F.L., Liu, S.X., (2007) Acta Physico-Chimica Sinica, 23, p. 438
dc.descriptionTeli, S.B., Gokavi, G.S., Aminabhavi, T.M., (2007) Separ. Purif. Tech., 56, p. 150
dc.descriptionShin, Y., Kim, K.S., Kim, B., (2008) Polymer-Korea, 32, p. 421
dc.descriptionBiswal, D., Hilt, J.Z., (2006) Polymer, 47, p. 7355
dc.descriptionMiyata, T., Asami, N., Uragami, T., (1999) Nature, 399, p. 766
dc.descriptionOmichi, H., (1995) Nucl. Instrum. Meth. B, 105, p. 302
dc.descriptionMoura, M.R., Rubira, A.F., Muniz, E.C., (2008) Polím. Ciěncia Tecnol, 18, p. 132
dc.descriptionOuwerx, C., Velings, N., Mestdagh, M.M., Axelos, M.A.V., (1998) Polym. Gels Netw, 6, p. 293
dc.descriptionLee, K.Y., Rowley, J.A., Eiselt, P., Moy, E.M., Bouhadir, K.H., Mooney, D.J., (2000) Macromolecules, 33, p. 4291
dc.descriptionPaulino, A.T., Campese, G.M., Fávaro, S.L., Guilherme, M.R., Tambourgi, E.B., Muniz, E.C., (2007) E Polymer, 122, p. 1
dc.descriptionMoura, M.R., Guilherme, M.R., Campese, G.M., Radovanovic, E., Rubira, A.F., Muniz, E.C., (2005) Eur. Polym. J., 41, p. 2845
dc.languagept
dc.publisher
dc.relationPolimeros
dc.rightsaberto
dc.sourceScopus
dc.titleMorphology Of Temperature-sensitive And Ph-responsive Ipn-hydrogels For Application As Biomaterial For Cell Growth [morfologia De Hidrogéis-ipn Termo-sensíveis E Ph-responsivos Para Aplica ção Como Biomaterial Na Cultura De Células]
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución