Artículos de revistas
Biological Effects Of Anionic Meso-tetrakis (para-sulfonatophenyl) Porphyrins Modulated By The Metal Center. Studies In Rat Liver Mitochondria
Registro en:
Chemico-biological Interactions. , v. 181, n. 3, p. 400 - 408, 2009.
92797
10.1016/j.cbi.2009.07.012
2-s2.0-70349175565
Autor
Pessoto F.S.
Inada N.M.
Nepomuceno M.d.F.
Ruggiero A.C.
Nascimento O.R.
Vercesi A.E.
Nantes I.L.
Institución
Resumen
In this paper, we present a study about the influence of the porphyrin metal center and meso ligands on the biological effects of meso-tetrakis porphyrins. Different from the cationic meso-tetrakis 4-N-methyl pyridinium (Mn(III)TMPyP), the anionic Mn(III) meso-tetrakis (para-sulfonatophenyl) porphyrin (Mn(III)TPPS4) exhibited no protector effect against Fe(citrate)-induced lipid oxidation. Mn(III)TPPS4 did not protect mitochondria against endogenous hydrogen peroxide and only delayed the swelling caused by tert-BuOOH and Ca2+. Fe(III)TPPS4 exacerbated the effect of the tert-BuOOH, and both porphyrins did not significantly affect Fe(II)citrate-induced swelling. Consistently, Fe(III)TPPS4 predominantly promotes the homolytic cleavage of peroxides and exhibits catalytic efficiency ten-fold higher than Mn(III)TPPS4. 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