The Amazonian Fruit Byrsonima Crassifolia Effectively Scavenges Reactive Oxygen And Nitrogen Species And Protects Human Erythrocytes Against Oxidative Damage

dc.creatorMariutti L.R.B.
dc.creatorRodrigues E.
dc.creatorChiste R.C.
dc.creatorFernandes E.
dc.creatorMercadante A.Z.
dc.date2014
dc.date2015-06-25T17:50:37Z
dc.date2015-11-26T15:34:46Z
dc.date2015-06-25T17:50:37Z
dc.date2015-11-26T15:34:46Z
dc.date.accessioned2018-03-28T22:43:21Z
dc.date.available2018-03-28T22:43:21Z
dc.identifier
dc.identifierFood Research International. Elsevier Ltd, v. 64, n. , p. 618 - 625, 2014.
dc.identifier9639969
dc.identifier10.1016/j.foodres.2014.07.032
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84907852522&partnerID=40&md5=636b50fadec03beb4a8d6ccdeeb0ca32
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85871
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85871
dc.identifier2-s2.0-84907852522
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1263062
dc.descriptionA hydrophilic extract of murici (Byrsonima crassifolia), a fruit native to the North and Northeast regions of Brazil, was evaluated in relation to its phenolic composition and in vitro antioxidant potential against some physiologically relevant reactive oxygen and nitrogen species. Additionally, the protective effect of murici extract against peroxyl radical (ROO<sup/>)-induced toxicity to human erythrocytes was also determined. The major phenolic compound, determined by HPLC-DAD-MSn, was quercetin (2.72 ± 0.35μg/mL). The extract was able to scavenge ROO<sup/> (0.30 ± 0.04μmoltroloxequivalent/mg), hypochlorous acid (IC50=10.0 ± 0.1μg/mL), hydroxyl radical (IC50=7 ± 1μg/mL) and peroxynitrite anion (IC50=21.0 ± 0.6μg/mL and 17.0 ± 1.6μg/mL, respectively, in absence and presence of NaHCO3). Human erythrocytes were subjected to oxidative damage, but murici extract was not able to inhibit hemolysis, even at the highest tested concentration. On the other hand, the extract inhibited hemoglobin oxidation (IC50=271 ± 44μg/mL), lipid peroxidation (1000μg/mL) by 48 ± 5%, depletion of glutathione (100μg/mL) by 49 ± 2% and formation of its oxidized form (100μg/mL) by 96 ± 4%.
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dc.languageen
dc.publisherElsevier Ltd
dc.relationFood Research International
dc.rightsfechado
dc.sourceScopus
dc.titleThe Amazonian Fruit Byrsonima Crassifolia Effectively Scavenges Reactive Oxygen And Nitrogen Species And Protects Human Erythrocytes Against Oxidative Damage
dc.typeArtículos de revistas


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