An Asp49 Phospholipase A2 From Snake Venom Induces Cyclooxygenase-2 Expression And Prostaglandin E2 Production Via Activation Of Nf- κ B, P38mapk, And Pkc In Macrophages

dc.creatorMoreira V.
dc.creatorLomonte B.
dc.creatorVinolo M.A.R.
dc.creatorCuri R.
dc.creatorGutierrez J.M.
dc.creatorTeixeira C.
dc.date2014
dc.date2015-06-25T17:50:31Z
dc.date2015-11-26T15:33:46Z
dc.date2015-06-25T17:50:31Z
dc.date2015-11-26T15:33:46Z
dc.date.accessioned2018-03-28T22:42:21Z
dc.date.available2018-03-28T22:42:21Z
dc.identifier
dc.identifierMediators Of Inflammation. Hindawi Publishing Corporation, v. 2014, n. , p. - , 2014.
dc.identifier9629351
dc.identifier10.1155/2014/105879
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84899949347&partnerID=40&md5=73d83cc9bc0e19e0fcbadfe06baed313
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85852
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85852
dc.identifier2-s2.0-84899949347
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1262829
dc.descriptionPhospholipases A2 (PLA2) are key enzymes for production of lipid mediators. We previously demonstrated that a snake venom sPLA2 named MT-III leads to prostaglandin (PG)E2 biosynthesis in macrophages by inducing the expression of cyclooxygenase-2 (COX-2). Herein, we explored the molecular mechanisms and signaling pathways leading to these MT-III-induced effects. Results demonstrated that MT-III induced activation of the transcription factor NF-κB in isolated macrophages. By using NF-κB selective inhibitors, the involvement of this factor in MT-III-induced COX-2 expression and PGE2 production was demonstrated. Moreover, MT-III-induced COX-2 protein expression and PGE 2 release were attenuated by pretreatment of macrophages with SB202190, and Ly294002, and H-7-dihydro compounds, indicating the involvement of p38MAPK, PI3K, and PKC pathways, respectively. Consistent with this, MT-III triggered early phosphorylation of p38MAPK, PI3K, and PKC. Furthermore, SB202190, H-7-dihydro, but not Ly294002 treatment, abrogated activation of NF-κB induced by MT-III. Altogether, these results show for the first time that the induction of COX-2 protein expression and PGE2 release, which occur via NF-κB activation induced by the sPLA2-MT-III in macrophages, are modulated by p38MAPK and PKC, but not by PI3K signaling proteins. © 2014 Vanessa Moreira et al.
dc.description2014
dc.description
dc.description
dc.description
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dc.languageen
dc.publisherHindawi Publishing Corporation
dc.relationMediators of Inflammation
dc.rightsaberto
dc.sourceScopus
dc.titleAn Asp49 Phospholipase A2 From Snake Venom Induces Cyclooxygenase-2 Expression And Prostaglandin E2 Production Via Activation Of Nf- κ B, P38mapk, And Pkc In Macrophages
dc.typeArtículos de revistas


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