Epicardial And Pericardial Fat In Type 2 Diabetes: Favourable Effects Of Biliopancreatic Diversion

dc.creatorVasques A.C.J.
dc.creatorPareja J.C.
dc.creatorSouza J.R.M.
dc.creatorYamanaka A.
dc.creatorde Oliveira M.d.S.
dc.creatorNovaes F.S.
dc.creatorChaim E.A.
dc.creatorPiccinini F.
dc.creatorDalla Man C.
dc.creatorCobelli C.
dc.creatorGeloneze B.
dc.date2014
dc.date2015-06-25T17:50:31Z
dc.date2015-11-26T15:33:41Z
dc.date2015-06-25T17:50:31Z
dc.date2015-11-26T15:33:41Z
dc.date.accessioned2018-03-28T22:42:16Z
dc.date.available2018-03-28T22:42:16Z
dc.identifier
dc.identifierObesity Surgery. , v. , n. , p. - , 2014.
dc.identifier9608923
dc.identifier10.1007/s11695-014-1400-1
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84906211732&partnerID=40&md5=5ee05eda5e5bdfb638026873b7f18811
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85850
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85850
dc.identifier2-s2.0-84906211732
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1262807
dc.descriptionPurpose Ectopic fat is often identified in obese subjects who are susceptible to the development of type 2 diabetes mellitus (T2DM). The ectopic fat favours the decrease in insulin sensitivity (IS) and adiponectin levels. We aimed to evaluate the effect of biliopancreatic diversion (BPD) on the accumulation of ectopic fat, adiponectin levels and IS in obese with T2DM. Materials and Methods A nonrandomised controlled study was performed on sixty-eight women: 19 lean-control (23.0 ± 2.2 kg/m2) and 18 obese-control (35.0 ± 4.8 kg/m2) with normal glucose tolerance and 31 obese with T2DM (36.3 ± 3.7 kg/m2). Of the 31 diabetic women, 20 underwent BPD and were reassessed 1 month and 12 months after surgery. The subcutaneous adipose tissue, visceral adipose tissue, epicardial adipose tissue and pericardial adipose tissue were evaluated by ultrasonography. The IS was assessed by a hyperglycaemic clamp, applying the minimal model of glucose. Results One month after surgery, there was a reduction in visceral and subcutaneous adipose tissues, whereas epicardial and pericardial adipose tissues exhibited significant reduction at the 12-month assessment (p < 0.01). Adiponectin levels and IS were normalised 1 month after surgery, resembling lean-control values and elevated above the obese-control values (p < 0.01). After 12 months, the improvement in IS and adiponectin was maintained, and 17 of the 20 operated patients exhibited fasting glucose and glycated haemoglobin within the normal range. Conclusions After BPD, positive physiological adaptations occurred in grade I and II obese patients with T2DM. These adaptations relate to the restoration of IS and decreased adiposopathy and explain the acute (1 month) and chronic (12 months) improvements in the glycaemic control. © 2014 Springer Science+Business Media New York.
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dc.description
dc.description
dc.description
dc.languageen
dc.publisher
dc.relationObesity Surgery
dc.rightsfechado
dc.sourceScopus
dc.titleEpicardial And Pericardial Fat In Type 2 Diabetes: Favourable Effects Of Biliopancreatic Diversion
dc.typeArtículos de revistas


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